E3 ubiquitin-protein ligase TRIM15 (TRIM15)

About E3 ubiquitin-protein ligase TRIM15

E3 ubiquitin-protein ligase TRIM15 (TRIM15) is a protein from Homo sapiens identified by UniProt accession Q9C019, 465 residues long. MolForge cross-references it against 0 known binders and 47 disease associations.

Target properties

Protein name	E3 ubiquitin-protein ligase TRIM15
UniProt accession	Q9C019
Gene	TRIM15
Organism	Homo sapiens
Length	465 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (47)

Diseases linked to this target (Open Targets).

low density lipoprotein cholesterol measurement · score 0.13
neoplasm · score 0.09
non-small cell lung carcinoma · score 0.09
Barrett's esophagus · score 0.08
hepatocellular carcinoma · score 0.07
chronic obstructive pulmonary disease · score 0.07
gastric adenocarcinoma · score 0.06
melanoma · score 0.06
Parkinson disease · score 0.06
systemic lupus erythematosus · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9C019-F1	alphafold	PREDICTED	83.85	—

Amino-acid sequence (465 residues)

MPATPSLKVV HELPACTLCA GPLEDAVTIP CGHTFCRLCL PALSQMGAQS SGKILLCPLC QEEEQAETPM APVPLGPLGE TYCEEHGEKI YFFCENDAEF LCVFCREGPT HQAHTVGFLD EAIQPYRDRL RSRLEALSTE RDEIEDVKCQ EDQKLQVLLT QIESKKHQVE TAFERLQQEL EQQRCLLLAR LRELEQQIWK ERDEYITKVS EEVTRLGAQV KELEEKCQQP ASELLQDVRV NQSRCEMKTF VSPEAISPDL VKKIRDFHRK ILTLPEMMRM FSENLAHHLE IDSGVITLDP QTASRSLVLS EDRKSVRYTR QKKSLPDSPL RFDGLPAVLG FPGFSSGRHR WQVDLQLGDG GGCTVGVAGE GVRRKGEMGL SAEDGVWAVI ISHQQCWAST SPGTDLPLSE IPRGVRVALD YEAGQVTLHN AQTQEPIFTF TASFSGKVFP FFAVWKKGSC LTLKG

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards