About E3 ubiquitin-protein ligase TRIM9
E3 ubiquitin-protein ligase TRIM9 (TRIM9) is a protein
from Homo sapiens identified by UniProt accession
Q9C026, 710 residues long.
MolForge cross-references it against 0 known binders and
58 disease associations.
Target properties
| Protein name | E3 ubiquitin-protein ligase TRIM9 |
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| UniProt accession | Q9C026 |
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| Gene | TRIM9 |
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| Organism | Homo sapiens |
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| Length | 710 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (58)
Diseases linked to this target (Open Targets).
- PHF-tau measurement · score 0.18
- adolescent idiopathic scoliosis · score 0.14
- neoplasm · score 0.09
- urinary bladder carcinoma · score 0.07
- schizencephaly · score 0.04
- non-small cell lung carcinoma · score 0.04
- sub-cortical nodular heterotopia · score 0.04
- Chudley-McCullough syndrome · score 0.03
- Cortical dysgenesis with pontocerebellar hypoplasia due to TUBB3 mutation · score 0.03
- maternal uniparental disomy of chromosome 20 · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9C026-F1 | alphafold | PREDICTED | 82.92 | — |
Amino-acid sequence (710 residues)
MEEMEEELKC PVCGSFYREP IILPCSHNLC QACARNILVQ TPESESPQSH RAAGSGVSDY DYLDLDKMSL YSEADSGYGS YGGFASAPTT PCQKSPNGVR VFPPAMPPPA THLSPALAPV PRNSCITCPQ CHRSLILDDR GLRGFPKNRV LEGVIDRYQQ SKAAALKCQL CEKAPKEATV MCEQCDVFYC DPCRLRCHPP RGPLAKHRLV PPAQGRVSRR LSPRKVSTCT DHELENHSMY CVQCKMPVCY QCLEEGKHSS HEVKALGAMW KLHKSQLSQA LNGLSDRAKE AKEFLVQLRN MVQQIQENSV EFEACLVAQC DALIDALNRR KAQLLARVNK EHEHKLKVVR DQISHCTVKL RQTTGLMEYC LEVIKENDPS GFLQISDALI RRVHLTEDQW GKGTLTPRMT TDFDLSLDNS PLLQSIHQLD FVQVKASSPV PATPILQLEE CCTHNNSATL SWKQPPLSTV PADGYILELD DGNGGQFREV YVGKETMCTV DGLHFNSTYN ARVKAFNKTG VSPYSKTLVL QTSEVAWFAF DPGSAHSDII LSNDNLTVTC SSYDDRVVLG KTGFSKGIHY WELTVDRYDN HPDPAFGVAR MDVMKDVMLG KDDKAWAMYV DNNRSWFMHN NSHTNRTEGG ITKGATIGVL LDLNRKNLTF FINDEQQGPI AFDNVEGLFF PAVSLNRNVQ VTLHTGLPVP DFYSSRASIA
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