E3 ubiquitin-protein ligase TRIM7 (TRIM7)

About E3 ubiquitin-protein ligase TRIM7

E3 ubiquitin-protein ligase TRIM7 (TRIM7) is a protein from Homo sapiens identified by UniProt accession Q9C029, 511 residues long. MolForge cross-references it against 0 known binders and 47 disease associations.

Target properties

Protein name	E3 ubiquitin-protein ligase TRIM7
UniProt accession	Q9C029
Gene	TRIM7
Organism	Homo sapiens
Length	511 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (47)

Diseases linked to this target (Open Targets).

body height · score 0.32
gut microbiome measurement · score 0.27
glioblastoma · score 0.08
osteosarcoma · score 0.07
gonorrhea · score 0.07
Sepsis · score 0.06
neoplasm · score 0.06
non-small cell lung carcinoma · score 0.05
hepatocellular carcinoma · score 0.04
BMI-adjusted waist-hip ratio · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9C029-F1	alphafold	PREDICTED	85.48	—

Amino-acid sequence (511 residues)

MAAVGPRTGP GTGAEALALA AELQGEATCS ICLELFREPV SVECGHSFCR ACIGRCWERP GAGSVGAATR APPFPLPCPQ CREPARPSQL RPNRQLAAVA TLLRRFSLPA AAPGEHGSQA AAARAAAARC GQHGEPFKLY CQDDGRAICV VCDRAREHRE HAVLPLDEAV QEAKELLESR LRVLKKELED CEVFRSTEKK ESKELLKQMA AEQEKVGAEF QALRAFLVEQ EGRLLGRLEE LSREVAQKQN ENLAQLGVEI TQLSKLSSQI QETAQKPDLD FLQEFKSTLS RCSNVPGPKP TTVSSEMKNK VWNVSLKTFV LKGMLKKFKE DLRGELEKEE KVELTLDPDT ANPRLILSLD LKGVRLGERA QDLPNHPCRF DTNTRVLASC GFSSGRHHWE VEVGSKDGWA FGVARESVRR KGLTPFTPEE GVWALQLNGG QYWAVTSPER SPLSCGHLSR VRVALDLEVG AVSFYAVEDM RHLYTFRVNF QERVFPLFSV CSTGTYLRIW P

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards