About Tripartite motif-containing protein 5
Tripartite motif-containing protein 5 (TRIM5) is a protein
from Homo sapiens identified by UniProt accession
Q9C035, 493 residues long.
MolForge cross-references it against 0 known binders and
122 disease associations.
Target properties
| Protein name | Tripartite motif-containing protein 5 |
|---|
| UniProt accession | Q9C035 |
|---|
| Gene | TRIM5 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 493 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (122)
Diseases linked to this target (Open Targets).
- mean platelet volume · score 0.27
- low density lipoprotein cholesterol measurement · score 0.26
- alkaline phosphatase measurement · score 0.25
- platelet count · score 0.25
- sex hormone-binding globulin measurement · score 0.25
- serum alanine aminotransferase measurement · score 0.24
- coronary artery disease · score 0.23
- apolipoprotein B measurement · score 0.23
- aspartate aminotransferase measurement · score 0.22
- bilirubin measurement · score 0.22
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9C035-F1 | alphafold | PREDICTED | 85.94 | — |
Amino-acid sequence (493 residues)
MASGILVNVK EEVTCPICLE LLTQPLSLDC GHSFCQACLT ANHKKSMLDK GESSCPVCRI SYQPENIRPN RHVANIVEKL REVKLSPEGQ KVDHCARHGE KLLLFCQEDG KVICWLCERS QEHRGHHTFL TEEVAREYQV KLQAALEMLR QKQQEAEELE ADIREEKASW KTQIQYDKTN VLADFEQLRD ILDWEESNEL QNLEKEEEDI LKSLTNSETE MVQQTQSLRE LISDLEHRLQ GSVMELLQGV DGVIKRTENV TLKKPETFPK NQRRVFRAPD LKGMLEVFRE LTDVRRYWVD VTVAPNNISC AVISEDKRQV SSPKPQIIYG ARGTRYQTFV NFNYCTGILG SQSITSGKHY WEVDVSKKTA WILGVCAGFQ PDAMCNIEKN ENYQPKYGYW VIGLEEGVKC SAFQDSSFHT PSVPFIVPLS VIICPDRVGV FLDYEACTVS FFNITNHGFL IYKFSHCSFS QPVFPYLNPR KCGVPMTLCS PSS
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