E3 ubiquitin-protein ligase TRIM4 (TRIM4)

About E3 ubiquitin-protein ligase TRIM4

E3 ubiquitin-protein ligase TRIM4 (TRIM4) is a protein from Homo sapiens identified by UniProt accession Q9C037, 500 residues long. MolForge cross-references it against 0 known binders and 43 disease associations.

Target properties

Protein name	E3 ubiquitin-protein ligase TRIM4
UniProt accession	Q9C037
Gene	TRIM4
Organism	Homo sapiens
Length	500 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (43)

Diseases linked to this target (Open Targets).

serum metabolite measurement · score 0.24
metabolite measurement · score 0.21
estrone measurement · score 0.09
hormone measurement · score 0.08
hepatocellular carcinoma · score 0.08
lymphocyte count · score 0.06
bone density · score 0.06
neoplasm · score 0.06
HbA1c measurement · score 0.05
Ataxia-telangiectasia · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9C037-F1	alphafold	PREDICTED	83.37	—

Amino-acid sequence (500 residues)

MEAEDIQEEL TCPICLDYFQ DPVSIECGHN FCRGCLHRNW APGGGPFPCP ECRHPSAPAA LRPNWALARL TEKTQRRRLG PVPPGLCGRH WEPLRLFCED DQRPVCLVCR ESQEHQTHAM APIDEAFESY RTGNFDIHVD EWKRRLIRLL LYHFKQEEKL LKSQRNLVAK MKKVMHLQDV EVKNATQWKD KIKSQRMRIS TEFSKLHNFL VEEEDLFLQR LNKEEEETKK KLNENTLKLN QTIASLKKLI LEVGEKSQAP TLELLQNPKE VLTRSEIQDV NYSLEAVKVK TVCQIPLMKE MLKRFQVAVN LAEDTAHPKL VFSQEGRYVK NTASASSWPV FSSAWNYFAG WRNPQKTAFV ERFQHLPCVL GKNVFTSGKH YWEVESRDSL EVAVGVCRED VMGITDRSKM SPDVGIWAIY WSAAGYWPLI GFPGTPTQQE PALHRVGVYL DRGTGNVSFY SAVDGVHLHT FSCSSVSRLR PFFWLSPLAS LVIPPVTDRK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards