About Tripartite motif-containing protein 2
Tripartite motif-containing protein 2 (TRIM2) is a protein
from Homo sapiens identified by UniProt accession
Q9C040, 744 residues long.
MolForge cross-references it against 0 known binders and
311 disease associations.
Target properties
| Protein name | Tripartite motif-containing protein 2 |
|---|
| UniProt accession | Q9C040 |
|---|
| Gene | TRIM2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 744 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (311)
Diseases linked to this target (Open Targets).
- Charcot-Marie-Tooth disease type 2R · score 0.66
- electrocardiography · score 0.47
- sex hormone-binding globulin measurement · score 0.40
- low density lipoprotein cholesterol measurement · score 0.37
- high density lipoprotein cholesterol measurement · score 0.37
- total cholesterol measurement · score 0.36
- alkaline phosphatase measurement · score 0.36
- heel bone mineral density · score 0.33
- serum albumin measurement · score 0.32
- apolipoprotein A 1 measurement · score 0.30
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9C040-F1 | alphafold | PREDICTED | 84.59 | — |
Amino-acid sequence (744 residues)
MASEGTNIPS PVVRQIDKQF LICSICLERY KNPKVLPCLH TFCERCLQNY IPAHSLTLSC PVCRQTSILP EKGVAALQNN FFITNLMDVL QRTPGSNAEE SSILETVTAV AAGKPLSCPN HDGNVMEFYC QSCETAMCRE CTEGEHAEHP TVPLKDVVEQ HKASLQVQLD AVNKRLPEID SALQFISEII HQLTNQKASI VDDIHSTFDE LQKTLNVRKS VLLMELEVNY GLKHKVLQSQ LDTLLQGQES IKSCSNFTAQ ALNHGTETEV LLVKKQMSEK LNELADQDFP LHPRENDQLD FIVETEGLKK SIHNLGTILT TNAVASETVA TGEGLRQTII GQPMSVTITT KDKDGELCKT GNAYLTAELS TPDGSVADGE ILDNKNGTYE FLYTVQKEGD FTLSLRLYDQ HIRGSPFKLK VIRSADVSPT TEGVKRRVKS PGSGHVKQKA VKRPASMYST GKRKENPIED DLIFRVGTKG RNKGEFTNLQ GVAASTNGKI LIADSNNQCV QIFSNDGQFK SRFGIRGRSP GQLQRPTGVA VHPSGDIIIA DYDNKWVSIF SSDGKFKTKI GSGKLMGPKG VSVDRNGHII VVDNKACCVF IFQPNGKIVT RFGSRGNGDR QFAGPHFAAV NSNNEIIITD FHNHSVKVFN QEGEFMLKFG SNGEGNGQFN APTGVAVDSN GNIIVADWGN SRIQVFDGSG SFLSYINTSA DPLYGPQGLA LTSDGHVVVA DSGNHCFKVY RYLQ
Explore Tripartite motif-containing protein 2 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets