Keratin, type I cytoskeletal 23 (KRT23)

About Keratin, type I cytoskeletal 23

Keratin, type I cytoskeletal 23 (KRT23) is a protein from Homo sapiens identified by UniProt accession Q9C075, 422 residues long. MolForge cross-references it against 0 known binders and 81 disease associations.

Target properties

Protein name	Keratin, type I cytoskeletal 23
UniProt accession	Q9C075
Gene	KRT23
Organism	Homo sapiens
Length	422 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (81)

Diseases linked to this target (Open Targets).

head and neck squamous cell carcinoma · score 0.19
clear cell renal carcinoma · score 0.18
glioblastoma multiforme · score 0.18
prostate adenocarcinoma · score 0.18
ovarian cancer · score 0.18
breast adenocarcinoma · score 0.18
mitochondrial DNA depletion syndrome 4a · score 0.07
colorectal cancer · score 0.05
metabolite measurement · score 0.04
neoplasm · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9C075-F1	alphafold	PREDICTED	77.03	—

Amino-acid sequence (422 residues)

MNSGHSFSQT PSASFHGAGG GWGRPRSFPR APTVHGGAGG ARISLSFTTR SCPPPGGSWG SGRSSPLLGG NGKATMQNLN DRLASYLEKV RALEEANMKL ESRILKWHQQ RDPGSKKDYS QYEENITHLQ EQIVDGKMTN AQIILLIDNA RMAVDDFNLK YENEHSFKKD LEIEVEGLRR TLDNLTIVTT DLEQEVEGMR KELILMKKHH EQEMEKHHVP SDFNVNVKVD TGPREDLIKV LEDMRQEYEL IIKKKHRDLD TWYKEQSAAM SQEAASPATV QSRQGDIHEL KRTFQALEID LQTQYSTKSA LENMLSETQS RYSCKLQDMQ EIISHYEEEL TQLRHELERQ NNEYQVLLGI KTHLEKEITT YRRLLEGESE GTREESKSSM KVSATPKIKA ITQETINGRL VLCQVNEIQK HA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards