About Serine/threonine-protein kinase DCLK3
Serine/threonine-protein kinase DCLK3 (DCLK3) is a protein
from Homo sapiens identified by UniProt accession
Q9C098, 648 residues long.
MolForge cross-references it against 0 known binders and
209 disease associations.
Target properties
| Protein name | Serine/threonine-protein kinase DCLK3 |
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| UniProt accession | Q9C098 |
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| Gene | DCLK3 |
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| Organism | Homo sapiens |
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| Length | 648 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (8)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (209)
Diseases linked to this target (Open Targets).
- psychotic symptom measurement · score 0.31
- bipolar disorder · score 0.31
- schizophrenia · score 0.29
- autism spectrum disorder · score 0.27
- attention deficit hyperactivity disorder · score 0.27
- unipolar depression · score 0.26
- bipolar I disorder · score 0.24
- obsessive-compulsive disorder · score 0.19
- Tourette syndrome · score 0.19
- anorexia nervosa · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9C098-F1 | alphafold | PREDICTED | 63.03 | — |
Amino-acid sequence (648 residues)
MGKEPLTLKS IQVAVEELYP NKARALTLAQ HSRAPSPRLR SRLFSKALKG DHRCGETETP KSCSEVAGCK AAMRHQGKIP EELSLDDRAR TQKKWGRGKW EPEPSSKPPR EATLEERHAR GEKHLGVEIE KTSGEIIRCE KCKRERELQQ SLERERLSLG TSELDMGKGP MYDVEKLVRT RSCRRSPEAN PASGEEGWKG DSHRSSPRNP TQELRRPSKS MDKKEDRGPE DQESHAQGAA KAKKDLVEVL PVTEEGLREV KKDTRPMSRS KHGGWLLREH QAGFEKLRRT RGEEKEAEKE KKPCMSGGRR MTLRDDQPAK LEKEPKTRPE ENKPERPSGR KPRPMGIIAA NVEKHYETGR VIGDGNFAVV KECRHRETRQ AYAMKIIDKS RLKGKEDMVD SEILIIQSLS HPNIVKLHEV YETDMEIYLI LEYVQGGDLF DAIIESVKFP EPDAALMIMD LCKALVHMHD KSIVHRDLKP ENLLVQRNED KSTTLKLADF GLAKHVVRPI FTVCGTPTYV APEILSEKGY GLEVDMWAAG VILYILLCGF PPFRSPERDQ DELFNIIQLG HFEFLPPYWD NISDAAKDLV SRLLVVDPKK RYTAHQVLQH PWIETAGKTN TVKRQKQVSP SSEGHFRSQH KRVVEQVS
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