About Leucine-rich repeat and coiled-coil domain-containing protein 1
Leucine-rich repeat and coiled-coil domain-containing protein 1 (LRRCC1) is a protein
from Homo sapiens identified by UniProt accession
Q9C099, 1032 residues long.
MolForge cross-references it against 0 known binders and
45 disease associations.
Target properties
| Protein name | Leucine-rich repeat and coiled-coil domain-containing protein 1 |
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| UniProt accession | Q9C099 |
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| Gene | LRRCC1 |
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| Organism | Homo sapiens |
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| Length | 1032 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (45)
Diseases linked to this target (Open Targets).
- Joubert syndrome and related disorders · score 0.26
- body mass index · score 0.08
- body weight · score 0.06
- PHF-tau measurement · score 0.05
- azoospermia · score 0.05
- male infertility with teratozoospermia due to single gene mutation · score 0.04
- intelligence · score 0.04
- spermatogenic failure 65 · score 0.03
- spermatogenic failure 72 · score 0.03
- spermatogenic failure 56 · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9C099-F1 | alphafold | PREDICTED | 73.96 | — |
Amino-acid sequence (1032 residues)
MEAAAAVVAA EAEVENEDGD SSCGDVCFMD KGLQSISELS LDSTLHAVNL HCNNISKIEA IDHIWNLQHL DLSSNQISRI EGLNTLTKLC TLNLSCNLIT KVEGLEELIN LTRLNVSYNH IDDLSGLIPL HGIKHKLRYI DLHSNRIDSI HHLLQCMVGL HFLTNLILEK DGDDNPVCRL PGYRAVILQT LPQLRILDCK NIFGEPVNLT EINSSQLQCL EGLLDNLVSS DSPLNISEDE IIDRMPVITA PIDELVPLEQ FASTPSDAVL TSFMSVCQSS EPEKNNHEND LQNEIKLQKL DDQILQLLNE TSNSIDNVLE KDPRPKRDTD ITSESDYGNR KECNRKVPRR SKIPYDAKTI QTIKHHNKNY NSFVSCNRKM KPPYLKELYV SSSLANCPML QESEKPKTEI IKVDQSHSED NTYQSLVEQL DQEREKRWRA EQAENKLMDY IDELHKHANE KEDIHSLALL TTDRLKEIIF RERNSKGQLE VMVHKLQNEI KKLTVELMKA KDQQEDHLKH LRTLEKTLEK MERQKRQQQA AQIRLIQEVE LKASAADREI YLLRTSLHRE REQAQQLHQL LALKEQEHRK ELETREFFTD ADFQDALAKE IAKEEKKHEQ MIKEYQEKID VLSQQYMDLE NEFRIALTVE ARRFQDVKDG FENVATELAK SKHALIWAQR KENESSSLIK DLTCMVKEQK TKLAEVSKLK QETAANLQNQ INTLEILIED DKQKSIQIEL LKHEKVQLIS ELAAKESLIF GLRTERKVWG HELAQQGSSL AQNRGKLEAQ IESLSRENEC LRKTNESDSD ALRIKCKIID DQTETIRKLK DCLQEKDEHI KRLQEKITEI EKCTQEQLDE KSSQLDEVLE KLERHNERKE KLKQQLKGKE VELEEIRKAY STLNRKWHDK GELLCHLETQ VKEVKEKFEN KEKKLKAERD KSIELQKNAM EKLHSMDDAF KRQVDAIVEA HQAEIAQLAN EKQKCIDSAN LKVHQIEKEM RELLEETCKN KKTMEAKIKQ LAFALNEIQQ DM
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