About Cilia- and flagella-associated protein 74
Cilia- and flagella-associated protein 74 (CFAP74) is a protein
from Homo sapiens identified by UniProt accession
Q9C0B2, 1584 residues long.
MolForge cross-references it against 0 known binders and
34 disease associations.
Target properties
| Protein name | Cilia- and flagella-associated protein 74 |
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| UniProt accession | Q9C0B2 |
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| Gene | CFAP74 |
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| Organism | Homo sapiens |
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| Length | 1584 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (34)
Diseases linked to this target (Open Targets).
- ciliary dyskinesia, primary, 49, without situs inversus · score 0.60
- primary ciliary dyskinesia · score 0.42
- body mass index · score 0.28
- influenza A (H1N1) · score 0.25
- Infertility · score 0.18
- infertility · score 0.18
- lifestyle measurement · score 0.16
- mean corpuscular hemoglobin concentration · score 0.11
- body weight · score 0.11
- waist circumference · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9C0B2-F1 | alphafold | PREDICTED | 69.31 | — |
Amino-acid sequence (1584 residues)
MEDDGSLLPE DELLADALLL EDERDELEDP EFDIKCLLQE AEDDVDPGHS SSVKELDTDA DKLKKKTAED RTQAFHLRQN LSALDKMHEE QELFTEKMRG ELRACRQRRD LIDKQQEAVA AEIATEEEAG NMAAVGRLQA VSRRLFAELE NERDLQSRTE AVLKESENTM WHIEIQEGRL EAFRTADREE VEATGRRLQV RAAEQLCREQ EALGKVERNR LLRIRKSLNT QKELGLRHQK LLEDARKNHK VAVRFLKASL GRIREQEKKE EMECHEYMRR RMDAVVALKG SISANRDTLR KFQAWDRAKA ELAEQRVQAE KKAILAQGRD AFRHLVHQRR RQELEAQKRA FEEEQKLRKQ EIISRILKEE AEEEKRKKQH PPTSARHRLT LRDKTWNYIS DFCKKTTVPT NTYTLDYEAA AGPGPSRLLE VVSSELIQGD PGASSEEETL AEPEISGLWN EDYKPYQVPK EDVDRKPVGG TKMDKDILER TVERLRSRVV HKQVVWGREF QGRPFNSKPE LLHFQDFDIG KVYKKKITLV NTTYTINYCK LVGVEEHLRD FIHVDFDPPG PLSAGMSCEV LVTFKPMINK DLEGNISFLA QTGEFSVPLK CSTKKCSLSL DKELIDFGSY VVGETTSRTI TLTNVGGLGT TFKFLPASEP CEMDDSQSAL KLSSLLTYED KSLYDKAATS FSEQQLEGTE SSQADMQSRK ELEKLDKEQE EEQPAEPERL TTVIPPSEEQ TEITLGEVTE GEIGPFSSIK VPIVFTPVVP GDVQARFKVT FKNPQCPTLH FRVVGVAIDV PVWVPKPSVD LKICMYDRLY QDSVLVHTRS KAALRLKFEV CKELRAHLEL LPKTGYIQAQ SSYSVQLKFL PRHSLPEDAG RYFDKETRVL EAPMTIWVAD QNKPVGFTVH AIVTTSDLEL SPSEVDFGYC TIYEAIRTEI SLHNHSLLPQ EFGFVRLPKF VDVQPNDGFG TILPLETLQF CVIFQPTKAE EHRFQLTCKS EINRCFKLSC RAVGVHPPLE LSHYQIKFAA TALYDTSVAT VYVINSHLSM SSPTHSKPRI GSEDASPMGP TSFEFLLPPD SPITISPSVG TVWPGKRCLV QVAFRPVLPE KLIRQEALPL LNKEMETKSF RKNMAPQRKD LHGLSFSVLR AQNRDKLFKV SVPHVLEMRK RELRPSSDEY QAARATLLRA FQAKFDTFVV PCVVASGDIK DRKGSEPLSF SPHNTLYLEL WCPTVAPSVV VTSHKGKTIF NFGDVAVGHR SIKKISIQNV SPEDLALDFS LLNPNGPFVL LNHSSLLRAG GTQVLVLSFS PHESILAQET LDIITKRGTL TLTLMGTGVA SMITCSIEGS VLNMGYVIAG ESVSSGFKLQ NNSLLPIKFS MHLDSLSSTR GRGQQQLPQF LSSPSQRTEV VGTQNLNGQS VFSVAPVKGV MDPGKTQDFT VTFSPDHESL YFSDKLQVVL FEKKISHQIL LKGAACQHMM FVEGGDPLDV PVESLTAIPV FDPRHREEAE ELRPILVTLD YIQFDTDTPA PPATRELQVG CIRTTQPSPK KPDHPLMVSA LLQLRGDVKE TYKVIFVAQV LTGP
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