About Semaphorin-4C
Semaphorin-4C (SEMA4C) is a protein
from Homo sapiens identified by UniProt accession
Q9C0C4, 833 residues long.
MolForge cross-references it against 0 known binders and
94 disease associations.
Target properties
| Protein name | Semaphorin-4C |
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| UniProt accession | Q9C0C4 |
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| Gene | SEMA4C |
|---|
| Organism | Homo sapiens |
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| Length | 833 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (94)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.44
- cortical thickness · score 0.11
- mean corpuscular volume · score 0.10
- systolic blood pressure · score 0.08
- hepatocellular carcinoma · score 0.08
- Griscelli syndrome type 3 · score 0.08
- colorectal carcinoma · score 0.07
- body height · score 0.07
- non-small cell lung carcinoma · score 0.07
- calf circumference measurement · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9C0C4-F1 | alphafold | PREDICTED | 81.75 | — |
Amino-acid sequence (833 residues)
MAPHWAVWLL AARLWGLGIG AEVWWNLVPR KTVSSGELAT VVRRFSQTGI QDFLTLTLTE PTGLLYVGAR EALFAFSMEA LELQGAISWE APVEKKTECI QKGKNNQTEC FNFIRFLQPY NASHLYVCGT YAFQPKCTYV NMLTFTLEHG EFEDGKGKCP YDPAKGHAGL LVDGELYSAT LNNFLGTEPI ILRNMGPHHS MKTEYLAFWL NEPHFVGSAY VPESVGSFTG DDDKVYFFFR ERAVESDCYA EQVVARVARV CKGDMGGART LQRKWTTFLK ARLACSAPNW QLYFNQLQAM HTLQDTSWHN TTFFGVFQAQ WGDMYLSAIC EYQLEEIQRV FEGPYKEYHE EAQKWDRYTD PVPSPRPGSC INNWHRRHGY TSSLELPDNI LNFVKKHPLM EEQVGPRWSR PLLVKKGTNF THLVADRVTG LDGATYTVLF IGTGDGWLLK AVSLGPWVHL IEELQLFDQE PMRSLVLSQS KKLLFAGSRS QLVQLPVADC MKYRSCADCV LARDPYCAWS VNTSRCVAVG GHSGSLLIQH VMTSDTSGIC NLRGSKKVRP TPKNITVVAG TDLVLPCHLS SNLAHARWTF GGRDLPAEQP GSFLYDARLQ ALVVMAAQPR HAGAYHCFSE EQGARLAAEG YLVAVVAGPS VTLEARAPLE NLGLVWLAVV ALGAVCLVLL LLVLSLRRRL REELEKGAKA TERTLVYPLE LPKEPTSPPF RPCPEPDEKL WDPVGYYYSD GSLKIVPGHA RCQPGGGPPS PPPGIPGQPL PSPTRLHLGG GRNSNANGYV RLQLGGEDRG GLGHPLPELA DELRRKLQQR QPLPDSNPEE SSV
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