About Phosphatase and actin regulator 1
Phosphatase and actin regulator 1 (PHACTR1) is a protein
from Homo sapiens identified by UniProt accession
Q9C0D0, 580 residues long.
MolForge cross-references it against 0 known binders and
129 disease associations.
Target properties
| Protein name | Phosphatase and actin regulator 1 |
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| UniProt accession | Q9C0D0 |
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| Gene | PHACTR1 |
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| Organism | Homo sapiens |
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| Length | 580 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (129)
Diseases linked to this target (Open Targets).
- coronary artery disease · score 0.54
- myocardial infarction · score 0.53
- migraine disorder · score 0.52
- angina pectoris · score 0.52
- developmental and epileptic encephalopathy · score 0.51
- systolic blood pressure · score 0.51
- pulse pressure measurement · score 0.50
- cardiovascular disease · score 0.45
- coronary artery calcification · score 0.45
- Myocardial Ischemia · score 0.45
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9C0D0-F1 | alphafold | PREDICTED | 62.45 | — |
Amino-acid sequence (580 residues)
MDYPKMDYFL DVESAHRLLD VESAQRFFYS QGAQARRATL LLPPTLMAAS SEDDIDRRPI RRVRSKSDTP YLAEARISFN LGAAEEVERL AAMRSDSLVP GTHTPPIRRR SKFANLGRIF KPWKWRKKKS EKFKHTSAAL ERKISMRQSR EELIKRGVLK EIYDKDGELS ISNEEDSLEN GQSLSSSQLS LPALSEMEPV PMPRDPCSYE VLQPSDIMDG PDPGAPVKLP CLPVKLSPPL PPKKVMICMP VGGPDLSLVS YTAQKSGQQG VAQHHHTVLP SQIQHQLQYG SHGQHLPSTT GSLPMHPSGC RMIDELNKTL AMTMQRLESS EQRVPCSTSY HSSGLHSGDG VTKAGPMGLP EIRQVPTVVI ECDDNKENVP HESDYEDSSC LYTREEEEEE EDEDDDSSLY TSSLAMKVCR KDSLAIKLSN RPSKRELEEK NILPRQTDEE RLELRQQIGT KLTRRLSQRP TAEELEQRNI LKPRNEQEEQ EEKREIKRRL TRKLSQRPTV EELRERKILI RFSDYVEVAD AQDYDRRADK PWTRLTAADK AAIRKELNEF KSTEMEVHEL SRHLTRFHRP
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