About Zinc finger protein 518B
Zinc finger protein 518B (ZNF518B) is a protein
from Homo sapiens identified by UniProt accession
Q9C0D4, 1074 residues long.
MolForge cross-references it against 0 known binders and
34 disease associations.
Target properties
| Protein name | Zinc finger protein 518B |
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| UniProt accession | Q9C0D4 |
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| Gene | ZNF518B |
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| Organism | Homo sapiens |
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| Length | 1074 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (34)
Diseases linked to this target (Open Targets).
- urate measurement · score 0.45
- body height · score 0.35
- uric acid measurement · score 0.30
- neurodegenerative disease · score 0.28
- serum metabolite measurement · score 0.25
- gout · score 0.22
- drug use measurement · score 0.13
- Hashimoto's thyroiditis · score 0.09
- glomerular filtration rate · score 0.07
- mean corpuscular volume · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9C0D4-F1 | alphafold | PREDICTED | 42.97 | — |
Amino-acid sequence (1074 residues)
MKDIGQQLYT THLNGGHNSL TMSPKQPDAN GAPRPNRQEA QTLLYQGSEA EAAMMTIATC AKCKSVHKIS LQDLQKGTGK DGMYVCFQCS LGAAPPNFHF VSNNSSATHV GNKTENFSSS VNSKFKVRNF KPGKYYCDKC RFSTKDPLQY KKHTLQHEEI KFICSHCSYI SYTKGEFQRH LVKHTGIFPY QCEYCDYGAI RNDYIVKHTK RVHERAGAKR PVKAVAKLEP KRTGTSKQNP ELLKASNPRT TFQNKWSDQL SGFSLHANKD KMHNIMLLPE PKEYQKDVVC IPNKMTLSEP NEVNLFENKN VEVEVLSPAK EPVQPGMPLT VVAPAELVVP ANCLAQLIDV KVVNGTQQLV LKLFPLEENN CLEAGRDNGG NSERMVKEKG SNEQEKVLSA EKTKSLTVDG NVGKLVGIDS FQPSVQKQLK NVKWVRSYDF IMPNSSVHNN GKSFINSETI EDFQKKNNLY PHRTAFPSVA LKGHSLASVF KNSVLRSLGA ASNPFPYKAA VCFAESGRNL HSSSQQLLPF AASPATCSFS GEKGLLPVSE NDLESTSKVN IPVKVVSSNR KQEDNQTEEH KAVSTVGQIS SQHKSEYLHI NITGEDRSQQ PGDKPLELKN SERTNNTNDG PVISSVFSLS SGSENVPEGI KWNSSTSKIK SIELLRRKIA QLIESCGKPS SLASNSAHRR SVGQASKGTS KATSEGIQEI NVSLTGLGHS TGTLQKPPND GGITGNRQLT HQQIYPHFAD GSNRKTKSRV ARKAHVATPV LIPKGAVLRV LNSSENAHII EATCEAPVSI PCSERQLIKP VPFCPVRQAD SDLQPLRSER GPIDMSPNIE TPLRPKLRKE SAVCSTIHRK TGLLYGQQGS SELNKQGRLL SRSLSISRNK TKQVHLSRKK NKIQAEPSRC LKDPSIFQVA RQLRLIAAKP DQLIKCPRRN QPVIVLNHPD VDSPEVTNVM KVINKYKGNV LKVVLSERTR CQLGIRRHHV RLTYQNAEEA SQIKRQMMLK MKLKKVHKNN YQVVDSLPDD SSQCVFKCWF CGRLYEDQEE WMSHGQRHLI EATRDWDVLS SKGK
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