Putative Polycomb group protein ASXL3 (ASXL3)

About Putative Polycomb group protein ASXL3

Putative Polycomb group protein ASXL3 (ASXL3) is a protein from Homo sapiens identified by UniProt accession Q9C0F0, 2248 residues long. MolForge cross-references it against 0 known binders and 118 disease associations.

Target properties

Protein name	Putative Polycomb group protein ASXL3
UniProt accession	Q9C0F0
Gene	ASXL3
Organism	Homo sapiens
Length	2248 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (118)

Diseases linked to this target (Open Targets).

Severe feeding difficulties - failure to thrive - microcephaly due to ASXL3 deficiency · score 0.79
severe feeding difficulties-failure to thrive-microcephaly due to ASXL3 deficiency syndrome · score 0.67
genetic disorder · score 0.54
body mass index · score 0.51
Intellectual disability · score 0.47
lean body mass · score 0.47
autism spectrum disorder · score 0.46
wellbeing measurement · score 0.46
body weight · score 0.44
self reported educational attainment · score 0.43

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9C0F0-F1	alphafold	PREDICTED	39.37	—

Amino-acid sequence (2248 residues)

MKDKRKKKDR TWAEAARLAL EKHPNSPMTA KQILEVIQKE GLKETSGTSP LACLNAMLHT NTRIGDGTFF KIPGKSGLYA LKKEESSCPA DGTLDLVCES ELDGTDMAEA NAHGEENGVC SKQVTDEASS TRDSSLTNTA VQSKLVSSFQ QHTKKALKQA LRQQQKRRNG VSMMVNKTVP RVVLTPLKVS DEQSDSPSGS ESKNGEADSS DKEMKHGQKS PTGKQTSQHL KRLKKSGLGH LKWTKAEDID IETPGSILVN TNLRALINKH TFASLPQHFQ QYLLLLLPEV DRQMGSDGIL RLSTSALNNE FFAYAAQGWK QRLAEGEFTP EMQLRIRQEI EKEKKTEPWK EKFFERFYGE KLGMSREESV KLTTGPNNAG AQSSSSCGTS GLPVSAQTAL AEQQPKSMKS PASPEPGFCA TLCPMVEIPP KDIMAELESE DILIPEESVI QEEIAEEVET SICECQDENH KTIPEFSEEA ESLTNSHEEP QIAPPEDNLE SCVMMNDVLE TLPHIEVKIE GKSESPQEEM TVVIDQLEVC DSLIPSTSSM THVSDTEHKE SETAVETSTP KIKTGSSSLE GQFPNEGIAI DMELQSDPEE QLSENACISE TSFSSESPEG ACTSLPSPGG ETQSTSEESC TPASLETTFC SEVSSTENTD KYNQRNSTDE NFHASLMSEI SPISTSPEIS EASLMSNLPL TSEASPVSNL PLTSETSPMS DLPLTSETSS VSSMLLTSET TFVSSLPLPS ETSPISNSSI NERMAHQQRK SPSVSEEPLS PQKDESSATA KPLGENLTSQ QKNLSNTPEP IIMSSSSIAP EAFPSEDLHN KTLSQQTCKS HVDTEKPYPA SIPELASTEM IKVKNHSVLQ RTEKKVLPSP LELSVFSEGT DNKGNELPSA KLQDKQYISS VDKAPFSEGS RNKTHKQGST QSRLETSHTS KSSEPSKSPD GIRNESRDSE ISKRKTAEQH SFGICKEKRA RIEDDQSTRN ISSSSPPEKE QPPREEPRVP PLKIQLSKIG PPFIIKSQPV SKPESRASTS TSVSGGRNTG ARTLADIKAR AQQARAQREA AAAAAVAAAA SIVSGAMGSP GEGGKTRTLA HIKEQTKAKL FAKHQARAHL FQTSKETRLP PPLSSKEGPP NLEVSSTPET KMEGSTGVII VNPNCRSPSN KSAHLRETTT VLQQSLNPSK LPETATDLSV HSSDENIPVS HLSEKIVSST SSENSSVPML FNKNSVPVSV CSTAISGAIK EHPFVSSVDK SSVLMSVDSA NTTISACNIS MLKTIQGTDT PCIAIIPKCI ESTPISATTE GSSISSSMDD KQLLISSSSA SNLVSTQYTS VPTPSIGNNL PNLSTSSVLI PPMGINNRFP SEKIAIPGSE EQATVSMGTT VRAALSCSDS VAVTDSLVAH PTVAMFTGNM LTINSYDSPP KLSAESLDKN SGPRNRADNS GKPQQPPGGF APAAINRSIP CKVIVDHSTT LTSSLSLTVS VESSEASLDL QGRPVRTEAS VQPVACPQVS VISRPEPVAN EGIDHSSTFI AASAAKQDSK TLPATCTSLR ELPLVPDKLN EPTAPSHNFA EQARGPAPFK SEADTTCSNQ YNPSNRICWN DDGMRSTGQP LVTHSGSSKQ KEYLEQSCPK AIKTEHANYL NVSELHPRNL VTNVALPVKS ELHEADKGFR MDTEDFPGPE LPPPAAEGAS SVQQTQNMKA STSSPMEEAI SLATDALKRV PGAGSSGCRL SSVEANNPLV TQLLQGNLPL EKVLPQPRLG AKLEINRLPL PLQTTSVGKT APERNVEIPP SSPNPDGKGY LAGTLAPLQM RKRENHPKKR VARTVGEHTQ VKCEPGKLLV EPDVKGVPCV ISSGISQLGH SQPFKQEWLN KHSMQNRIVH SPEVKQQKRL LPSCSFQQNL FHVDKNGGFH TDAGTSHRQQ FYQMPVAARG PIPTAALLQA SSKTPVGCNA FAFNRHLEQK GLGEVSLSSA PHQLRLANML SPNMPMKEGD EVGGTAHTMP NKALVHPPPP PPPPPPPPLA LPPPPPPPPP LPPPLPNAEV PSDQKQPPVT METTKRLSWP QSTGICSNIK SEPLSFEEGL SSSCELGMKQ VSYDQNEMKE QLKAFALKSA DFSSYLLSEP QKPFTQLAAQ KMQVQQQQQL CGNYPTIHFG STSFKRAASA IEKSIGILGS GSNPATGLSG QNAQMPVQNF ADSSNADELE LKCSCRLKAM IVCKGCGAFC HDDCIGPSKL CVACLVVR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards