Zinc finger protein 436 (ZNF436)

About Zinc finger protein 436

Zinc finger protein 436 (ZNF436) is a protein from Homo sapiens identified by UniProt accession Q9C0F3, 470 residues long. MolForge cross-references it against 0 known binders and 32 disease associations.

Target properties

Protein name	Zinc finger protein 436
UniProt accession	Q9C0F3
Gene	ZNF436
Organism	Homo sapiens
Length	470 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (32)

Diseases linked to this target (Open Targets).

glomerular filtration rate · score 0.41
neurodegenerative disease · score 0.39
creatinine measurement · score 0.37
BMI-adjusted waist circumference · score 0.29
sex hormone-binding globulin measurement · score 0.29
BMI-adjusted waist-hip ratio · score 0.28
waist-hip ratio · score 0.19
risk-taking behaviour · score 0.16
cystatin C measurement · score 0.16
eosinophil percentage of leukocytes · score 0.13

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9C0F3-F1	alphafold	PREDICTED	77.50	—

Amino-acid sequence (470 residues)

MAATLLMAGS QAPVTFEDMA MYLTREEWRP LDAAQRDLYR DVMQENYGNV VSLDFEIRSE NEVNPKQEIS EDVQFGTTSE RPAENAEENP ESEEGFESGD RSERQWGDLT AEEWVSYPLQ PVTDLLVHKE VHTGIRYHIC SHCGKAFSQI SDLNRHQKTH TGDRPYKCYE CGKGFSRSSH LIQHQRTHTG ERPYDCNECG KSFGRSSHLI QHQTIHTGEK PHKCNECGKS FCRLSHLIQH QRTHSGEKPY ECEECGKSFS RSSHLAQHQR THTGEKPYEC NECGRGFSER SDLIKHYRVH TGERPYKCDE CGKNFSQNSD LVRHRRAHTG EKPYHCNECG ENFSRISHLV QHQRTHTGEK PYECNACGKS FSRSSHLITH QKIHTGEKPY ECNECWRSFG ERSDLIKHQR THTGEKPYEC VQCGKGFTQS SNLITHQRVH TGEKPYECTE CEKSFSRSSA LIKHKRVHTD

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards