Protein tweety homolog 3 (TTYH3)

About Protein tweety homolog 3

Protein tweety homolog 3 (TTYH3) is a protein from Homo sapiens identified by UniProt accession Q9C0H2, 523 residues long. MolForge cross-references it against 0 known binders and 90 disease associations.

Target properties

Protein name	Protein tweety homolog 3
UniProt accession	Q9C0H2
Gene	TTYH3
Organism	Homo sapiens
Length	523 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (90)

Diseases linked to this target (Open Targets).

creatinine measurement · score 0.26
platelet component distribution width · score 0.24
glioblastoma multiforme · score 0.18
appendicular lean mass · score 0.14
head and neck squamous cell carcinoma · score 0.12
hepatocellular carcinoma · score 0.08
urinary bladder carcinoma · score 0.07
breast cancer · score 0.07
cancer · score 0.07
body height · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9C0H2-F1	alphafold	PREDICTED	79.44	—

Amino-acid sequence (523 residues)

MAGVSYAAPW WVSLLHRLPH FDLSWEATSS QFRPEDTDYQ QALLLLGAAA LACLALDLLF LLFYSFWLCC RRRKSEEHLD ADCCCTAWCV IIATLVCSAG IAVGFYGNGE TSDGIHRATY SLRHANRTVA GVQDRVWDTA VGLNHTAEPS LQTLERQLAG RPEPLRAVQR LQGLLETLLG YTAAIPFWRN TAVSLEVLAE QVDLYDWYRW LGYLGLLLLD VIICLLVLVG LIRSSKGILV GVCLLGVLAL VISWGALGLE LAVSVGSSDF CVDPDAYVTK MVEEYSVLSG DILQYYLACS PRAANPFQQK LSGSHKALVE MQDVVAELLR TVPWEQPATK DPLLRVQEVL NGTEVNLQHL TALVDCRSLH LDYVQALTGF CYDGVEGLIY LALFSFVTAL MFSSIVCSVP HTWQQKRGPD EDGEEEAAPG PRQAHDSLYR VHMPSLYSCG SSYGSETSIP AAAHTVSNAP VTEYMSQNAN FQNPRCENTP LIGRESPPPS YTSSMRAKYL ATSQPRPDSS GSH

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards