About PITH domain-containing protein 1
PITH domain-containing protein 1 (PITHD1) is a protein
from Homo sapiens identified by UniProt accession
Q9GZP4, 211 residues long.
MolForge cross-references it against 0 known binders and
96 disease associations.
Target properties
| Protein name | PITH domain-containing protein 1 |
|---|
| UniProt accession | Q9GZP4 |
|---|
| Gene | PITHD1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 211 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
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| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (96)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.31
- azoospermia · score 0.11
- male infertility with teratozoospermia due to single gene mutation · score 0.10
- spermatogenic failure 72 · score 0.08
- spermatogenic failure 27 · score 0.08
- spermatogenic failure 18 · score 0.08
- spermatogenic failure 46 · score 0.08
- spermatogenic failure 65 · score 0.08
- spermatogenic failure 49 · score 0.08
- spermatogenic failure 43 · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9GZP4-F1 | alphafold | PREDICTED | 83.64 | — |
Amino-acid sequence (211 residues)
MSHGHSHGGG GCRCAAEREE PPEQRGLAYG LYLRIDLERL QCLNESREGS GRGVFKPWEE RTDRSKFVES DADEELLFNI PFTGNVKLKG IIIMGEDDDS HPSEMRLYKN IPQMSFDDTE REPDQTFSLN RDLTGELEYA TKISRFSNVY HLSIHISKNF GADTTKVFYI GLRGEWTELR RHEVTICNYE ASANPADHRV HQVTPQTHFI S
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