Immortalization up-regulated protein (IMUP)

About Immortalization up-regulated protein

Immortalization up-regulated protein (IMUP) is a protein from Homo sapiens identified by UniProt accession Q9GZP8, 106 residues long. MolForge cross-references it against 0 known binders and 31 disease associations.

Target properties

Protein name	Immortalization up-regulated protein
UniProt accession	Q9GZP8
Gene	IMUP
Organism	Homo sapiens
Length	106 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (31)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.39
cerebrospinal fluid biomarker measurement · score 0.22
blood protein measurement · score 0.17
mean platelet volume · score 0.17
platelet component distribution width · score 0.12
platelet count · score 0.07
ovarian epithelial tumor · score 0.05
cancer · score 0.04
D dimer measurement · score 0.03
papillary thyroid carcinoma · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9GZP8-F1	alphafold	PREDICTED	62.36	—

Amino-acid sequence (106 residues)

MEFDLGAALE PTSQKPGVGA GHGGDPKLSP HKVQGRSEAG AGPGPKQGHH SSSDSSSSSS DSDTDVKSHA AGSKQHESIP GKAKKPKVKK KEKGKKEKGK KKEAPH

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards