About Derlin-2
Derlin-2 (DERL2) is a protein
from Homo sapiens identified by UniProt accession
Q9GZP9, 239 residues long.
MolForge cross-references it against 0 known binders and
31 disease associations.
Target properties
| Protein name | Derlin-2 |
|---|
| UniProt accession | Q9GZP9 |
|---|
| Gene | DERL2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 239 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (31)
Diseases linked to this target (Open Targets).
- cystic fibrosis · score 0.46
- holoprosencephaly · score 0.46
- neurodegenerative disease · score 0.41
- hematocrit · score 0.14
- platelet component distribution width · score 0.05
- smoking status measurement · score 0.03
- diastolic blood pressure · score 0.03
- cancer · score 0.03
- neoplasm · score 0.02
- cholangiocarcinoma · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9GZP9-F1 | alphafold | PREDICTED | 81.59 | — |
Amino-acid sequence (239 residues)
MAYQSLRLEY LQIPPVSRAY TTACVLTTAA VQLELITPFQ LYFNPELIFK HFQIWRLITN FLFFGPVGFN FLFNMIFLYR YCRMLEEGSF RGRTADFVFM FLFGGFLMTL FGLFVSLVFL GQAFTIMLVY VWSRRNPYVR MNFFGLLNFQ APFLPWVLMG FSLLLGNSII VDLLGIAVGH IYFFLEDVFP NQPGGIRILK TPSILKAIFD TPDEDPNYNP LPEERPGGFA WGEGQRLGG
Explore Derlin-2 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets