About Single-stranded DNA cytosine deaminase
Single-stranded DNA cytosine deaminase (AICDA) is a protein
from Homo sapiens identified by UniProt accession
Q9GZX7, 198 residues long.
MolForge cross-references it against 0 known binders and
607 disease associations.
Target properties
| Protein name | Single-stranded DNA cytosine deaminase |
|---|
| UniProt accession | Q9GZX7 |
|---|
| Gene | AICDA |
|---|
| Organism | Homo sapiens |
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| Length | 198 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (607)
Diseases linked to this target (Open Targets).
- hyper-IgM syndrome type 2 · score 0.80
- genetic disorder · score 0.17
- hyper-IgM syndrome · score 0.16
- chronic lymphocytic leukemia · score 0.11
- diffuse large B-cell lymphoma · score 0.11
- acute lymphoblastic leukemia · score 0.11
- common variable immunodeficiency · score 0.11
- isolated agammaglobulinemia · score 0.09
- cancer · score 0.09
- BENTA disease · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9GZX7-F1 | alphafold | PREDICTED | 88.17 | — |
Amino-acid sequence (198 residues)
MDSLLMNRRK FLYQFKNVRW AKGRRETYLC YVVKRRDSAT SFSLDFGYLR NKNGCHVELL FLRYISDWDL DPGRCYRVTW FTSWSPCYDC ARHVADFLRG NPNLSLRIFT ARLYFCEDRK AEPEGLRRLH RAGVQIAIMT FKDYFYCWNT FVENHERTFK AWEGLHENSV RLSRQLRRIL LPLYEVDDLR DAFRTLGL
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