About Solute carrier family 22 member 4
Solute carrier family 22 member 4 (SLC22A4) is a protein
from Homo sapiens identified by UniProt accession
Q9H015, 551 residues long.
MolForge cross-references it against 0 known binders and
222 disease associations.
Target properties
| Protein name | Solute carrier family 22 member 4 |
|---|
| UniProt accession | Q9H015 |
|---|
| Gene | SLC22A4 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 551 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (222)
Diseases linked to this target (Open Targets).
- serum metabolite measurement · score 0.43
- rheumatoid arthritis · score 0.42
- inflammatory bowel disease · score 0.36
- Crohn's disease · score 0.36
- mean platelet volume · score 0.33
- neurodegenerative disease · score 0.33
- creatinine measurement · score 0.32
- diastolic blood pressure · score 0.32
- ulcerative colitis · score 0.31
- blood metabolite measurement · score 0.31
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9H015-F1 | alphafold | PREDICTED | 85.16 | — |
Amino-acid sequence (551 residues)
MRDYDEVIAF LGEWGPFQRL IFFLLSASII PNGFNGMSVV FLAGTPEHRC RVPDAANLSS AWRNNSVPLR LRDGREVPHS CSRYRLATIA NFSALGLEPG RDVDLGQLEQ ESCLDGWEFS QDVYLSTVVT EWNLVCEDNW KVPLTTSLFF VGVLLGSFVS GQLSDRFGRK NVLFATMAVQ TGFSFLQIFS ISWEMFTVLF VIVGMGQISN YVVAFILGTE ILGKSVRIIF STLGVCTFFA VGYMLLPLFA YFIRDWRMLL LALTVPGVLC VPLWWFIPES PRWLISQRRF REAEDIIQKA AKMNNIAVPA VIFDSVEELN PLKQQKAFIL DLFRTRNIAI MTIMSLLLWM LTSVGYFALS LDAPNLHGDA YLNCFLSALI EIPAYITAWL LLRTLPRRYI IAAVLFWGGG VLLFIQLVPV DYYFLSIGLV MLGKFGITSA FSMLYVFTAE LYPTLVRNMA VGVTSTASRV GSIIAPYFVY LGAYNRMLPY IVMGSLTVLI GILTLFFPES LGMTLPETLE QMQKVKWFRS GKKTRDSMET EENPKVLITA F
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