About DNA-dependent metalloprotease SPRTN
DNA-dependent metalloprotease SPRTN (SPRTN) is a protein
from Homo sapiens identified by UniProt accession
Q9H040, 489 residues long.
MolForge cross-references it against 0 known binders and
29 disease associations.
Target properties
| Protein name | DNA-dependent metalloprotease SPRTN |
|---|
| UniProt accession | Q9H040 |
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| Gene | SPRTN |
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| Organism | Homo sapiens |
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| Length | 489 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (29)
Diseases linked to this target (Open Targets).
- progeroid features-hepatocellular carcinoma predisposition syndrome · score 0.59
- hematocrit · score 0.34
- hemoglobin measurement · score 0.34
- genetic disorder · score 0.19
- breast adenocarcinoma · score 0.18
- age at menopause · score 0.18
- high altitude adaptation · score 0.17
- red blood cell density measurement · score 0.10
- lymphocyte percentage of leukocytes · score 0.09
- skin neoplasm · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9H040-F1 | alphafold | PREDICTED | 64.96 | — |
Amino-acid sequence (489 residues)
MDDDLMLALR LQEEWNLQEA ERDHAQESLS LVDASWELVD PTPDLQALFV QFNDQFFWGQ LEAVEVKWSV RMTLCAGICS YEGKGGMCSI RLSEPLLKLR PRKDLVETLL HEMIHAYLFV TNNDKDREGH GPEFCKHMHR INSLTGANIT VYHTFHDEVD EYRRHWWRCN GPCQHRPPYY GYVKRATNRE PSAHDYWWAE HQKTCGGTYI KIKEPENYSK KGKGKAKLGK EPVLAAENKD KPNRGEAQLV IPFSGKGYVL GETSNLPSPG KLITSHAINK TQDLLNQNHS ANAVRPNSKI KVKFEQNGSS KNSHLVSPAV SNSHQNVLSN YFPRVSFANQ KAFRGVNGSP RISVTVGNIP KNSVSSSSQR RVSSSKISLR NSSKVTESAS VMPSQDVSGS EDTFPNKRPR LEDKTVFDNF FIKKEQIKSS GNDPKYSTTT AQNSSSSSSQ SKMVNCPVCQ NEVLESQINE HLDWCLEGDS IKVKSEESL
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