About Epsin-3
Epsin-3 (EPN3) is a protein
from Homo sapiens identified by UniProt accession
Q9H201, 632 residues long.
MolForge cross-references it against 0 known binders and
54 disease associations.
Target properties
| Protein name | Epsin-3 |
|---|
| UniProt accession | Q9H201 |
|---|
| Gene | EPN3 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 632 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (54)
Diseases linked to this target (Open Targets).
- breast cancer · score 0.08
- lung adenocarcinoma · score 0.07
- hereditary persistence of fetal hemoglobin-sickle cell disease syndrome · score 0.05
- hemoglobin D disease · score 0.05
- deafness · score 0.05
- delta-beta-thalassemia · score 0.05
- dominant beta-thalassemia · score 0.05
- non-small cell lung carcinoma · score 0.04
- hemoglobin E-beta-thalassemia syndrome · score 0.04
- hemoglobin C-beta-thalassemia syndrome · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9H201-F1 | alphafold | PREDICTED | 59.70 | — |
Amino-acid sequence (632 residues)
MTTSALRRQV KNIVHNYSEA EIKVREATSN DPWGPPSSLM SEIADLTFNT VAFTEVMGML WRRLNDSGKN WRHVYKALTL LDYLLKTGSE RVAHQCRENL YTIQTLKDFQ YIDRDGKDQG VNVREKVKQV MALLKDEERL RQERTHALKT KERMALEGIG IGSGQLGFSR RYGEDYSRSR GSPSSYNSSS SSPRYTSDLE QARPQTSGEE ELQLQLALAM SREEAEKPVP PASHRDEDLQ LQLALRLSRQ EHEKEVRSWQ GDGSPMANGA GAVVHHQRDR EPEREERKEE EKLKTSQSSI LDLADIFVPA LAPPSTHCSA DPWDIPGFRP NTEASGSSWG PSADPWSPIP SGTVLSRSQP WDLTPMLSSS EPWGRTPVLP AGPPTTDPWA LNSPHHKLPS TGADPWGASL ETSDTPGGAS TFDPFAKPPE STETKEGLEQ ALPSGKPSSP VELDLFGDPS PSSKQNGTKE PDALDLGILG EALTQPSKEA RACRTPESFL GPSASSLVNL DSLVKAPQVA KTRNPFLTGL SAPSPTNPFG AGEPGRPTLN QMRTGSPALG LAGGPVGAPL GSMTYSASLP LPLSSVPAGL TLPASVSVFP QAGAFAPQPL LPTPSSAGPR PPPPQTGTNP FL
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