About Kelch-like protein 31
Kelch-like protein 31 (KLHL31) is a protein
from Homo sapiens identified by UniProt accession
Q9H511, 634 residues long.
MolForge cross-references it against 0 known binders and
200 disease associations.
Target properties
| Protein name | Kelch-like protein 31 |
|---|
| UniProt accession | Q9H511 |
|---|
| Gene | KLHL31 |
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| Organism | Homo sapiens |
|---|
| Length | 634 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (200)
Diseases linked to this target (Open Targets).
- BMI-adjusted hip circumference · score 0.44
- neurofibrillary tangles measurement · score 0.33
- low density lipoprotein cholesterol measurement · score 0.29
- platelet component distribution width · score 0.15
- total cholesterol measurement · score 0.14
- triglyceride measurement · score 0.10
- myopathy · score 0.07
- cancer · score 0.07
- Distal myopathy, Nonaka type · score 0.06
- autosomal dominant mitochondrial myopathy with exercise intolerance · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9H511-F1 | alphafold | PREDICTED | 89.96 | — |
Amino-acid sequence (634 residues)
MAPKKKIVKK NKGDINEMTI IVEDSPLNKL NALNGLLEGG NGLSCISSEL TDASYGPNLL EGLSKMRQEN FLCDLVIGTK TKSFDVHKSV MASCSEYFYN ILKKDPSIQR VDLNDISPLG LATVIAYAYT GKLTLSLYTI GSIISAAVYL QIHTLVKMCS DFLIREMSVE NCMYVVNIAE TYSLKNAKAA AQKFIRDNFL EFAESDQFMK LTFEQINELL IDDDLQLPSE IVAFQIAMKW LEFDQKRVKY AADLLSNIRF GTISAQDLVN YVQSVPRMMQ DADCHRLLVD AMNYHLLPYH QNTLQSRRTR IRGGCRVLVT VGGRPGLTEK SLSRDILYRD PENGWSKLTE MPAKSFNQCV AVMDGFLYVA GGEDQNDARN QAKHAVSNFC RYDPRFNTWI HLASMNQKRT HFSLSVFNGL VYAAGGRNAE GSLASLECYV PSTNQWQPKT PLEVARCCHA SAVADGRVLV TGGYIANAYS RSVCAYDPAS DSWQELPNLS TPRGWHCAVT LSDRVYVMGG SQLGPRGERV DVLTVECYSP ATGQWSYAAP LQVGVSTAGV SALHGRAYLV GGWNEGEKKY KKCIQCFSPE LNEWTEDDEL PEATVGVSCC TLSMPNNVTR ESRASSVSSV PVSI
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