Ankyrin repeat and SOCS box protein 8 (ASB8)

About Ankyrin repeat and SOCS box protein 8

Ankyrin repeat and SOCS box protein 8 (ASB8) is a protein from Homo sapiens identified by UniProt accession Q9H765, 288 residues long. MolForge cross-references it against 0 known binders and 57 disease associations.

Target properties

Protein name	Ankyrin repeat and SOCS box protein 8
UniProt accession	Q9H765
Gene	ASB8
Organism	Homo sapiens
Length	288 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (57)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.20
clear cell renal carcinoma · score 0.18
platelet count · score 0.12
hematocrit · score 0.12
reticulocyte count · score 0.10
hemoglobin measurement · score 0.09
mean corpuscular hemoglobin concentration · score 0.09
age-related macular degeneration · score 0.08
macula measurement · score 0.08
X-linked retinal dysplasia · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9H765-F1	alphafold	PREDICTED	88.61	—

Amino-acid sequence (288 residues)

MSSSMWYIMQ SIQSKYSLSE RLIRTIAAIR SFPHDNVEDL IRGGADVNCT HGTLKPLHCA CMVSDADCVE LLLEKGAEVN ALDGYNRTAL HYAAEKDEAC VEVLLEYGAN PNALDGNRDT PLHWAAFKNN AECVRALLES GASVNALDYN NDTPLSWAAM KGNLESVSIL LDYGAEVRVI NLIGQTPISR LVALLVRGLG TEKEDSCFEL LHRAVGHFEL RKNGTMPREV ARDPQLCEKL TVLCSAPGTL KTLARYAVRR SLGLQYLPDA VKGLPLPASL KEYLLLLE

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards