About Nuclear body protein SP140-like protein
Nuclear body protein SP140-like protein (SP140L) is a protein
from Homo sapiens identified by UniProt accession
Q9H930, 580 residues long.
MolForge cross-references it against 0 known binders and
61 disease associations.
Target properties
| Protein name | Nuclear body protein SP140-like protein |
|---|
| UniProt accession | Q9H930 |
|---|
| Gene | SP140L |
|---|
| Organism | Homo sapiens |
|---|
| Length | 580 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (61)
Diseases linked to this target (Open Targets).
- erythrocyte count · score 0.38
- lymphocyte count · score 0.37
- total blood protein measurement · score 0.35
- red blood cell density measurement · score 0.33
- systolic blood pressure · score 0.33
- blood protein measurement · score 0.29
- serum non-albumin protein measurement · score 0.28
- lymphocyte percentage of leukocytes · score 0.28
- lymphoid leukemia · score 0.28
- neurodegenerative disease · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9H930-F1 | alphafold | PREDICTED | 67.87 | — |
Amino-acid sequence (580 residues)
MAGGGSDLST RGLNGGVSQV ANEMNHLPAH SQSLQRLFTE DQDVDEGLVY DTVFKHFKRH KLEISNAIKK TFPFLEGLRD RELITNKMFE DSEDSCRNLV PVQRVVYNVL SELEKTFNLS VLEALFSEVN MQEYPDLIHI YKSFKNAIQD KLSFQESDRK EREERPDIKL SLKQGEVPES PEARKESDQA CGKMDTVDIA NNSTLGKPKR KRRKKKGHGW SRMGTRTQKN NQQNDNSKAD GQLVSSEKKA NMNLKDLSKI RGRKRGKPGT HFTQSDRAPQ KRVRSRASRK HKDETVDFQA PLLPVTCGGV KGILHKEKLE QGTLAKCIQT EDGKWFTPME FEIKGGYARS KNWRLSVRCG GWPLRRLMEE GSLPNPPRIY YRNKKRILKS QNNSSVDPCM RNLDECEVCR DGGELFCCDT CSRVFHEDCH IPPVESEKTP WNCIFCRMKE SPGSQQCCQE SEVLERQMCP EEQLKCEFLL LKVYCCSESS FFAKIPYYYY IREACQGLKE PMWLDKIKKR LNEHGYPQVE GFVQDMRLIF QNHRASYKYK DFGQMGLRLE AEFEKDFKEV FAIQETNGNS
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