About E3 ubiquitin-protein ligase MARCHF7
E3 ubiquitin-protein ligase MARCHF7 (MARCHF7) is a protein
from Homo sapiens identified by UniProt accession
Q9H992, 704 residues long.
MolForge cross-references it against 0 known binders and
72 disease associations.
Target properties
| Protein name | E3 ubiquitin-protein ligase MARCHF7 |
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| UniProt accession | Q9H992 |
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| Gene | MARCHF7 |
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| Organism | Homo sapiens |
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| Length | 704 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (72)
Diseases linked to this target (Open Targets).
- platelet count · score 0.46
- neutrophil count · score 0.44
- platelet crit · score 0.42
- mean corpuscular hemoglobin concentration · score 0.38
- leukocyte count · score 0.38
- bone density · score 0.37
- urate measurement · score 0.37
- mean corpuscular volume · score 0.37
- myeloid white cell count · score 0.36
- aspartate aminotransferase measurement · score 0.35
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9H992-F1 | alphafold | PREDICTED | 50.06 | — |
Amino-acid sequence (704 residues)
MESKPSRIPR RISVQPSSSL SARMMSGSRG SSLNDTYHSR DSSFRLDSEY QSTSASASAS PFQSAWYSES EITQGARSRS QNQQRDHDSK RPKLSCTNCT TSAGRNVGNG LNTLSDSSWR HSQVPRSSSM VLGSFGTDLM RERRDLERRT DSSISNLMDY SHRSGDFTTS SYVQDRVPSY SQGARPKENS MSTLQLNTSS TNHQLPSEHQ TILSSRDSRN SLRSNFSSRE SESSRSNTQP GFSYSSSRDE APIISNSERV VSSQRPFQES SDNEGRRTTR RLLSRIASSM SSTFFSRRSS QDSLNTRSLN SENSYVSPRI LTASQSRSNV PSASEVPDNR ASEASQGFRF LRRRWGLSSL SHNHSSESDS ENFNQESEGR NTGPWLSSSL RNRCTPLFSR RRREGRDESS RIPTSDTSSR SHIFRRESNE VVHLEAQNDP LGAAANRPQA SAASSSATTG GSTSDSAQGG RNTGISGILP GSLFRFAVPP ALGSNLTDNV MITVDIIPSG WNSADGKSDK TKSAPSRDPE RLQKIKESLL LEDSEEEEGD LCRICQMAAA SSSNLLIEPC KCTGSLQYVH QDCMKKWLQA KINSGSSLEA VTTCELCKEK LELNLEDFDI HELHRAHANE QAEYEFISSG LYLVVLLHLC EQSFSDMMGN TNEPSTRVRF INLARTLQAH MEDLETSEDD SEEDGDHNRT FDIA
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