Calcium homeostasis modulator protein 2 (CALHM2)

About Calcium homeostasis modulator protein 2

Calcium homeostasis modulator protein 2 (CALHM2) is a protein from Homo sapiens identified by UniProt accession Q9HA72, 323 residues long. MolForge cross-references it against 0 known binders and 35 disease associations.

Target properties

Protein name	Calcium homeostasis modulator protein 2
UniProt accession	Q9HA72
Gene	CALHM2
Organism	Homo sapiens
Length	323 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (35)

Diseases linked to this target (Open Targets).

glomerular filtration rate · score 0.14
atrial fibrillation · score 0.05
systemic lupus erythematosus · score 0.05
self reported educational attainment · score 0.05
body height · score 0.04
cardiac arrhythmia · score 0.04
atrial flutter · score 0.04
pulse pressure measurement · score 0.04
rheumatoid arthritis · score 0.04
white matter microstructure measurement · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9HA72-F1	alphafold	PREDICTED	81.15	—

Amino-acid sequence (323 residues)

MAALIAENFR FLSLFFKSKD VMIFNGLVAL GTVGSQELFS VVAFHCPCSP ARNYLYGLAA IGVPALVLFI IGIILNNHTW NLVAECQHRR TKNCSAAPTF LLLSSILGRA AVAPVTWSVI SLLRGEAYVC ALSEFVDPSS LTAREEHFPS AHATEILARF PCKENPDNLS DFREEVSRRL RYESQLFGWL LIGVVAILVF LTKCLKHYCS PLSYRQEAYW AQYRANEDQL FQRTAEVHSR VLAANNVRRF FGFVALNKDD EELIANFPVE GTQPRPQWNA ITGVYLYREN QGLPLYSRLH KWAQGLAGNG AAPDNVEMAL LPS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards