About Probable cysteine--tRNA ligase, mitochondrial
Probable cysteine--tRNA ligase, mitochondrial (CARS2) is a protein
from Homo sapiens identified by UniProt accession
Q9HA77, 564 residues long.
MolForge cross-references it against 0 known binders and
120 disease associations.
Target properties
| Protein name | Probable cysteine--tRNA ligase, mitochondrial |
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| UniProt accession | Q9HA77 |
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| Gene | CARS2 |
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| Organism | Homo sapiens |
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| Length | 564 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (120)
Diseases linked to this target (Open Targets).
- Combined oxidative phosphorylation defect type 27 · score 0.75
- neurodegenerative disease · score 0.55
- genetic disorder · score 0.47
- mitochondrial oxidative phosphorylation disorder · score 0.46
- aspartate aminotransferase measurement · score 0.37
- serum alanine aminotransferase measurement · score 0.34
- serum gamma-glutamyl transferase measurement · score 0.29
- sex hormone-binding globulin measurement · score 0.24
- C-reactive protein measurement · score 0.21
- coronary artery disease · score 0.21
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9HA77-F1 | alphafold | PREDICTED | 86.06 | — |
Amino-acid sequence (564 residues)
MLRTTRGPGL GPPLLQAALG LGRAGWHWPA GRAASGGRGR AWLQPTGRET GVQVYNSLTG RKEPLIVAHA EAASWYSCGP TVYDHAHLGH ACSYVRFDII RRILTKVFGC SIVMVMGITD VDDKIIKRAN EMNISPASLA SLYEEDFKQD MAALKVLPPT VYLRVTENIP QIISFIEGII ARGNAYSTAK GNVYFDLKSR GDKYGKLVGV VPGPVGEPAD SDKRHASDFA LWKAAKPQEV FWASPWGPGR PGWHIECSAI ASMVFGSQLD IHSGGIDLAF PHHENEIAQC EVFHQCEQWG NYFLHSGHLH AKGKEEKMSK SLKNYITIKD FLKTFSPDVF RFFCLRSSYR SAIDYSDSAM LQAQQLLLGL GSFLEDARAY MKGQLACGSV REAMLWERLS STKRAVKAAL ADDFDTPRVV DAILGLAHHG NGQLRASLKE PEGPRSPAVF GAIISYFEQF FETVGISLAN QQYVSGDGSE ATLHGVVDEL VRFRQKVRQF ALAMPEATGD ARRQQLLERQ PLLEACDTLR RGLTAHGINI KDRSSTTSTW ELLDQRTKDQ KSAG
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