Phosphopantothenate--cysteine ligase (PPCS)

About Phosphopantothenate--cysteine ligase

Phosphopantothenate--cysteine ligase (PPCS) is a protein from Homo sapiens identified by UniProt accession Q9HAB8, 311 residues long. MolForge cross-references it against 0 known binders and 18 disease associations.

Target properties

Protein name	Phosphopantothenate--cysteine ligase
UniProt accession	Q9HAB8
Gene	PPCS
Organism	Homo sapiens
Length	311 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (18)

Diseases linked to this target (Open Targets).

dilated cardiomyopathy · score 0.62
neurodegenerative disease · score 0.56
lysosomal storage disease · score 0.37
familial isolated dilated cardiomyopathy · score 0.37
genetic disorder · score 0.19
pulse pressure measurement · score 0.14
systolic blood pressure · score 0.11
leukocyte count · score 0.08
primary peritoneal carcinoma · score 0.02
autosomal recessive dilated cardiomyopathy · score 0.01

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9HAB8-F1	alphafold	PREDICTED	93.82	—

Amino-acid sequence (311 residues)

MAEMDPVAEF PQPPGAARWA EVMARFAARL GAQGRRVVLV TSGGTKVPLE ARPVRFLDNF SSGRRGATSA EAFLAAGYGV LFLYRARSAF PYAHRFPPQT WLSALRPSGP ALSGLLSLEA EENALPGFAE ALRSYQEAAA AGTFLAVEFT TLADYLHLLQ AAAQALNPLG PSAMFYLAAA VSDFYVPVSE MPEHKIQSSG GPLQITMKMV PKLLSPLVKD WAPKAFIISF KLETDPAIVI NRARKALEIY QHQVVVANIL ESRQSFVFIV TKDSETKLLL SEEEIEKGVE IEEKIVDNLQ SRHTAFIGDR N

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards