Probable fibrosin-1 (FBRS)

About Probable fibrosin-1

Probable fibrosin-1 (FBRS) is a protein from Homo sapiens identified by UniProt accession Q9HAH7, 460 residues long. MolForge cross-references it against 0 known binders and 34 disease associations.

Target properties

Protein name	Probable fibrosin-1
UniProt accession	Q9HAH7
Gene	FBRS
Organism	Homo sapiens
Length	460 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (34)

Diseases linked to this target (Open Targets).

Short stature · score 0.34
neurodegenerative disease · score 0.32
mean platelet volume · score 0.07
HbA1c measurement · score 0.06
pulse pressure measurement · score 0.05
platelet count · score 0.05
C-reactive protein measurement · score 0.05
Crigler-Najjar syndrome type 2 · score 0.04
hemolytic anemia due to glutathione reductase deficiency · score 0.04
Rotor syndrome · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9HAH7-F1	alphafold	PREDICTED	52.27	—

Amino-acid sequence (460 residues)

MFEKYPGKME GLFRHNPYTA FPPAVPGLPP GLPPAVSFGS LQGAFQPKST NPELPPRLGP VPSGLSQKGT QIPDHFRPPL RKPGKWCAMH VRVAYMILRH QEKMKGDSHK LDFRNDLLPC LPGPYGALPP GQELSHPASL FTATGAVHAA ANPFTAAPGA HGPFLSPSTH IDPFGRPTSF ASLAALSNGA FGGLGSPTFN SGAVFAQKES PGAPPAFASP PDPWGRLHRS PLTFPAWVRP PEAARTPGSD KERPVERREP SITKEEKDRD LPFSRPQLRV SPATPKARAG EEGPRPTKES VRVKEERKEE AAAAAAAAAA AAAAAAAAAT GPQGLHLLFE RPRPPPFLGP SPPDRCAGFL EPTWLAAPPR LARPPRFYEA GEELTGPGAV AAARLYGLEP AHPLLYSRLA PPPPPAAAPG TPHLLSKTPP GALLGAPPPL VPAPRPSSPP RGPGPARADR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards