About Transcription factor COE2
Transcription factor COE2 (EBF2) is a protein
from Homo sapiens identified by UniProt accession
Q9HAK2, 575 residues long.
MolForge cross-references it against 0 known binders and
268 disease associations.
Target properties
| Protein name | Transcription factor COE2 |
|---|
| UniProt accession | Q9HAK2 |
|---|
| Gene | EBF2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 575 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (268)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.54
- systolic blood pressure · score 0.45
- Inguinal hernia · score 0.44
- vitamin D measurement · score 0.44
- diastolic blood pressure · score 0.42
- BMI-adjusted waist-hip ratio · score 0.41
- waist-hip ratio · score 0.41
- type 2 diabetes mellitus · score 0.40
- Palmar Fibromatosis · score 0.40
- platelet count · score 0.38
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9HAK2-F1 | alphafold | PREDICTED | 72.16 | — |
Amino-acid sequence (575 residues)
MFGIQDTLGR GPTLKEKSLG AEMDSVRSWV RNVGVVDANV AAQSGVALSR AHFEKQPPSN LRKSNFFHFV LALYDRQGQP VEIERTAFVD FVENDKEQGN EKTNNGTHYK LQLLYSNGVR TEQDLYVRLI DSVTKQPIAY EGQNKNPEMC RVLLTHEVMC SRCCEKKSCG NRNETPSDPV IIDRFFLKFF LKCNQNCLKT AGNPRDMRRF QVVLSTTVNV DGHVLAVSDN MFVHNNSKHG RRARRLDPSE ATPCIKAISP SEGWTTGGAM VIIIGDNFFD GLQVVFGTML VWSELITPHA IRVQTPPRHI PGVVEVTLSY KSKQFCKGAP GRFIYTALNE PTIDYGFQRL QKVIPRHPGD PERLAKEMLL KRAADLVEAL YGTPHNNQDI ILKRAADIAE ALYSVPRNPS QLPALSSSPA HSGMMGINSY GSQLGVSISE STQGNNQGYI RNTSSISPRG YSSSSTPQQS NYSTSSNSMN GYSNVPMANL GVPGSPGFLN GSPTGSPYGI MSSSPTVGSS STSSILPFSS SVFPAVKQKS AFAPVIRPQG SPSPACSSGN GNGFRAMTGL VVPPM
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