About Solute carrier family 28 member 3
Solute carrier family 28 member 3 (SLC28A3) is a protein
from Homo sapiens identified by UniProt accession
Q9HAS3, 691 residues long.
MolForge cross-references it against 0 known binders and
84 disease associations.
Target properties
| Protein name | Solute carrier family 28 member 3 |
|---|
| UniProt accession | Q9HAS3 |
|---|
| Gene | SLC28A3 |
|---|
| Organism | Homo sapiens |
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| Length | 691 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (84)
Diseases linked to this target (Open Targets).
- protein measurement · score 0.25
- smoking initiation · score 0.18
- smoking behavior · score 0.15
- smoking behaviour measurement · score 0.14
- cutaneous melanoma · score 0.12
- metabolite measurement · score 0.11
- risk-taking behaviour · score 0.07
- neutropenia, severe congenital, 2, autosomal dominant · score 0.05
- X-linked severe congenital neutropenia · score 0.04
- body weight · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9HAS3-F1 | alphafold | PREDICTED | 80.34 | — |
Amino-acid sequence (691 residues)
MELRSTAAPR AEGYSNVGFQ NEENFLENEN TSGNNSIRSR AVQSREHTNT KQDEEQVTVE QDSPRNREHM EDDDEEMQQK GCLERRYDTV CGFCRKHKTT LRHIIWGILL AGYLVMVISA CVLNFHRALP LFVITVAAIF FVVWDHLMAK YEHRIDEMLS PGRRLLNSHW FWLKWVIWSS LVLAVIFWLA FDTAKLGQQQ LVSFGGLIMY IVLLFLFSKY PTRVYWRPVL WGIGLQFLLG LLILRTDPGF IAFDWLGRQV QTFLEYTDAG ASFVFGEKYK DHFFAFKVLP IVVFFSTVMS MLYYLGLMQW IIRKVGWIML VTTGSSPIES VVASGNIFVG QTESPLLVRP YLPYITKSEL HAIMTAGFST IAGSVLGAYI SFGVPSSHLL TASVMSAPAS LAAAKLFWPE TEKPKITLKN AMKMESGDSG NLLEAATQGA SSSISLVANI AVNLIAFLAL LSFMNSALSW FGNMFDYPQL SFELICSYIF MPFSFMMGVE WQDSFMVARL IGYKTFFNEF VAYEHLSKWI HLRKEGGPKF VNGVQQYISI RSEIIATYAL CGFANIGSLG IVIGGLTSMA PSRKRDIASG AVRALIAGTV ACFMTACIAG ILSSTPVDIN CHHVLENAFN STFPGNTTKV IACCQSLLSS TVAKGPGEVI PGGNHSLYSL KGCCTLLNPS TFNCNGISNT F
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