About Sialate O-acetylesterase
Sialate O-acetylesterase (SIAE) is a protein
from Homo sapiens identified by UniProt accession
Q9HAT2, 523 residues long.
MolForge cross-references it against 0 known binders and
43 disease associations.
Target properties
| Protein name | Sialate O-acetylesterase |
|---|
| UniProt accession | Q9HAT2 |
|---|
| Gene | SIAE |
|---|
| Organism | Homo sapiens |
|---|
| Length | 523 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (43)
Diseases linked to this target (Open Targets).
- autoimmune disease · score 0.64
- blood protein measurement · score 0.25
- serum metabolite measurement · score 0.25
- neoplasm · score 0.08
- colorectal neoplasm · score 0.06
- neurofibrillary tangles measurement · score 0.05
- cancer · score 0.03
- prostate carcinoma · score 0.02
- type 1 diabetes mellitus · score 0.02
- medulloblastoma · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9HAT2-F1 | alphafold | PREDICTED | 91.90 | — |
Amino-acid sequence (523 residues)
MVAPGLVLGL VLPLILWADR SAGIGFRFAS YINNDMVLQK EPAGAVIWGF GTPGATVTVT LRQGQETIMK KVTSVKAHSD TWMVVLDPMK PGGPFEVMAQ QTLEKINFTL RVHDVLFGDV WLCSGQSNMQ MTVLQIFNAT RELSNTAAYQ SVRILSVSPI QAEQELEDLV AVDLQWSKPT SENLGHGYFK YMSAVCWLFG RHLYDTLQYP IGLIASSWGG TPIEAWSSGR SLKACGVPKQ GSIPYDSVTG PSKHSVLWNA MIHPLCNMTL KGVVWYQGES NINYNTDLYN CTFPALIEDW RETFHRGSQG QTERFFPFGL VQLSSDLSKK SSDDGFPQIR WHQTADFGYV PNPKMPNTFM AVAMDLCDRD SPFGSIHPRD KQTVAYRLHL GARALAYGEK NLTFEGPLPE KIELLAHKGL LNLTYYQQIQ VQKKDNKIFE ISCCSDHRCK WLPASMNTVS TQSLTLAIDS CHGTVVALRY AWTTWPCEYK QCPLYHPSSA LPAPPFIAFI TDQGPGHQSN VAK
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