About Guanine nucleotide-binding protein subunit beta-4
Guanine nucleotide-binding protein subunit beta-4 (GNB4) is a protein
from Homo sapiens identified by UniProt accession
Q9HAV0, 340 residues long.
MolForge cross-references it against 0 known binders and
96 disease associations.
Target properties
| Protein name | Guanine nucleotide-binding protein subunit beta-4 |
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| UniProt accession | Q9HAV0 |
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| Gene | GNB4 |
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| Organism | Homo sapiens |
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| Length | 340 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (96)
Diseases linked to this target (Open Targets).
- Charcot-Marie-Tooth disease dominant intermediate F · score 0.69
- Autosomal dominant intermediate Charcot-Marie-Tooth disease type F · score 0.66
- atrial fibrillation · score 0.38
- mitochondrial DNA measurement · score 0.29
- glioblastoma multiforme · score 0.28
- endometrial cancer · score 0.28
- diastolic blood pressure · score 0.27
- resting heart rate · score 0.27
- heart rate · score 0.27
- diet measurement · score 0.26
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9HAV0-F1 | alphafold | PREDICTED | 97.16 | — |
Amino-acid sequence (340 residues)
MSELEQLRQE AEQLRNQIQD ARKACNDATL VQITSNMDSV GRIQMRTRRT LRGHLAKIYA MHWGYDSRLL VSASQDGKLI IWDSYTTNKM HAIPLRSSWV MTCAYAPSGN YVACGGLDNI CSIYNLKTRE GNVRVSRELP GHTGYLSCCR FLDDSQIVTS SGDTTCALWD IETAQQTTTF TGHSGDVMSL SLSPDMRTFV SGACDASSKL WDIRDGMCRQ SFTGHVSDIN AVSFFPNGYA FATGSDDATC RLFDLRADQE LLLYSHDNII CGITSVAFSK SGRLLLAGYD DFNCNVWDTL KGDRAGVLAG HDNRVSCLGV TDDGMAVATG SWDSFLRIWN
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