About GrpE protein homolog 1, mitochondrial
GrpE protein homolog 1, mitochondrial (GRPEL1) is a protein
from Homo sapiens identified by UniProt accession
Q9HAV7, 217 residues long.
MolForge cross-references it against 0 known binders and
33 disease associations.
Target properties
| Protein name | GrpE protein homolog 1, mitochondrial |
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| UniProt accession | Q9HAV7 |
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| Gene | GRPEL1 |
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| Organism | Homo sapiens |
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| Length | 217 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (33)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.54
- blood protein measurement · score 0.25
- eosinophil count · score 0.24
- eosinophil percentage of leukocytes · score 0.22
- monocyte percentage of leukocytes · score 0.16
- monocyte count · score 0.08
- platelet crit · score 0.06
- platelet count · score 0.04
- mosaic loss of chromosome Y measurement · score 0.03
- leukocyte count · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9HAV7-F1 | alphafold | PREDICTED | 79.98 | — |
Amino-acid sequence (217 residues)
MAAQCVRLAR RSLPALALSL RPSPRLLCTA TKQKNSGQNL EEDMGQSEQK ADPPATEKTL LEEKVKLEEQ LKETVEKYKR ALADTENLRQ RSQKLVEEAK LYGIQAFCKD LLEVADVLEK ATQCVPKEEI KDDNPHLKNL YEGLVMTEVQ IQKVFTKHGL LKLNPVGAKF DPYEHEALFH TPVEGKEPGT VALVSKVGYK LHGRTLRPAL VGVVKEA
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