Transcription factor IIIB 50 kDa subunit (BRF2)

About Transcription factor IIIB 50 kDa subunit

Transcription factor IIIB 50 kDa subunit (BRF2) is a protein from Homo sapiens identified by UniProt accession Q9HAW0, 419 residues long. MolForge cross-references it against 0 known binders and 13 disease associations.

Target properties

Protein name	Transcription factor IIIB 50 kDa subunit
UniProt accession	Q9HAW0
Gene	BRF2
Organism	Homo sapiens
Length	419 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (13)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.49
balding measurement · score 0.11
Familial prostate cancer · score 0.11
prostate carcinoma · score 0.11
prostate cancer · score 0.11
body height · score 0.06
reticulocyte count · score 0.03
type 2 diabetes mellitus · score 0.03
leukocyte count · score 0.02
lymphocyte count · score 0.02

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9HAW0-F1	alphafold	PREDICTED	84.24	—

Amino-acid sequence (419 residues)

MPGRGRCPDC GSTELVEDSH YSQSQLVCSD CGCVVTEGVL TTTFSDEGNL REVTYSRSTG ENEQVSRSQQ RGLRRVRDLC RVLQLPPTFE DTAVAYYQQA YRHSGIRAAR LQKKEVLVGC CVLITCRQHN WPLTMGAICT LLYADLDVFS STYMQIVKLL GLDVPSLCLA ELVKTYCSSF KLFQASPSVP AKYVEDKEKM LSRTMQLVEL ANETWLVTGR HPLPVITAAT FLAWQSLQPA DRLSCSLARF CKLANVDLPY PASSRLQELL AVLLRMAEQL AWLRVLRLDK RSVVKHIGDL LQHRQSLVRS AFRDGTAEVE TREKEPPGWG QGQGEGEVGN NSLGLPQGKR PASPALLLPP CMLKSPKRIC PVPPVSTVTG DENISDSEIE QYLRTPQEVR DFQRAQAARQ AATSVPNPP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards