About UDP-glucuronosyltransferase 1A7
UDP-glucuronosyltransferase 1A7 (UGT1A7) is a protein
from Homo sapiens identified by UniProt accession
Q9HAW7, 530 residues long.
MolForge cross-references it against 0 known binders and
99 disease associations.
Target properties
| Protein name | UDP-glucuronosyltransferase 1A7 |
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| UniProt accession | Q9HAW7 |
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| Gene | UGT1A7 |
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| Organism | Homo sapiens |
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| Length | 530 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (2)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (99)
Diseases linked to this target (Open Targets).
- bilirubin measurement · score 0.69
- Gilbert syndrome · score 0.61
- Crigler-Najjar syndrome type 1 · score 0.56
- Crigler-Najjar syndrome type 2 · score 0.55
- Crigler-Najjar syndrome · score 0.53
- transient familial neonatal hyperbilirubinemia · score 0.52
- Hyperbilirubinemia · score 0.51
- porphyrin metabolism disease · score 0.51
- bilirubin metabolism disease · score 0.50
- genetic disorder · score 0.49
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9HAW7-F1 | alphafold | PREDICTED | 91.62 | — |
Amino-acid sequence (530 residues)
MARAGWTGLL PLYVCLLLTC GFAKAGKLLV VPMDGSHWFT MQSVVEKLIL RGHEVVVVMP EVSWQLGRSL NCTVKTYSTS YTLEDQDREF MVFADARWTA PLRSAFSLLT SSSNGIFDLF FSNCRSLFND RKLVEYLKES CFDAVFLDPF DACGLIVAKY FSLPSVVFAR GIFCHYLEEG AQCPAPLSYV PRLLLGFSDA MTFKERVWNH IMHLEEHLFC PYFFKNVLEI ASEILQTPVT AYDLYSHTSI WLLRTDFVLE YPKPVMPNMI FIGGINCHQG KPVPMEFEAY INASGEHGIV VFSLGSMVSE IPEKKAMAIA DALGKIPQTV LWRYTGTRPS NLANNTILVK WLPQNDLLGH PMTRAFITHA GSHGVYESIC NGVPMVMMPL FGDQMDNAKR METKGAGVTL NVLEMTSEDL ENALKAVIND KSYKENIMRL SSLHKDRPVE PLDLAVFWVE FVMRHKGAPH LRPAAHDLTW YQYHSLDVIG FLLAVVLTVA FITFKCCAYG YRKCLGKKGR VKKAHKSKTH
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