About UDP-glucuronosyltransferase 1A8
UDP-glucuronosyltransferase 1A8 (UGT1A8) is a protein
from Homo sapiens identified by UniProt accession
Q9HAW9, 530 residues long.
MolForge cross-references it against 0 known binders and
84 disease associations.
Target properties
| Protein name | UDP-glucuronosyltransferase 1A8 |
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| UniProt accession | Q9HAW9 |
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| Gene | UGT1A8 |
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| Organism | Homo sapiens |
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| Length | 530 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (84)
Diseases linked to this target (Open Targets).
- bilirubin measurement · score 0.66
- Gilbert syndrome · score 0.61
- Crigler-Najjar syndrome type 1 · score 0.56
- Crigler-Najjar syndrome type 2 · score 0.55
- Crigler-Najjar syndrome · score 0.53
- transient familial neonatal hyperbilirubinemia · score 0.52
- Hyperbilirubinemia · score 0.51
- porphyrin metabolism disease · score 0.50
- genetic disorder · score 0.49
- trait in response to irinotecan · score 0.48
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9HAW9-F1 | alphafold | PREDICTED | 91.46 | — |
Amino-acid sequence (530 residues)
MARTGWTSPI PLCVSLLLTC GFAEAGKLLV VPMDGSHWFT MQSVVEKLIL RGHEVVVVMP EVSWQLGKSL NCTVKTYSTS YTLEDLDREF MDFADAQWKA QVRSLFSLFL SSSNGFFNLF FSHCRSLFND RKLVEYLKES SFDAVFLDPF DACGLIVAKY FSLPSVVFAR GIACHYLEEG AQCPAPLSYV PRILLGFSDA MTFKERVRNH IMHLEEHLFC QYFSKNALEI ASEILQTPVT AYDLYSHTSI WLLRTDFVLD YPKPVMPNMI FIGGINCHQG KPLPMEFEAY INASGEHGIV VFSLGSMVSE IPEKKAMAIA DALGKIPQTV LWRYTGTRPS NLANNTILVK WLPQNDLLGH PMTRAFITHA GSHGVYESIC NGVPMVMMPL FGDQMDNAKR METKGAGVTL NVLEMTSEDL ENALKAVIND KSYKENIMRL SSLHKDRPVE PLDLAVFWVE FVMRHKGAPH LRPAAHDLTW YQYHSLDVIG FLLAVVLTVA FITFKCCAYG YRKCLGKKGR VKKAHKSKTH
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