About Dual specificity protein kinase CLK4
Dual specificity protein kinase CLK4 (CLK4) is a protein
from Homo sapiens identified by UniProt accession
Q9HAZ1, 481 residues long.
MolForge cross-references it against 0 known binders and
35 disease associations.
Target properties
| Protein name | Dual specificity protein kinase CLK4 |
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| UniProt accession | Q9HAZ1 |
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| Gene | CLK4 |
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| Organism | Homo sapiens |
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| Length | 481 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (12)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (35)
Diseases linked to this target (Open Targets).
- neuroinflammatory disorder · score 0.35
- esophageal squamous cell carcinoma · score 0.07
- granulocyte percentage of myeloid white cells · score 0.06
- neutrophil percentage of leukocytes · score 0.06
- cardiac hypertrophy · score 0.05
- prostate carcinoma · score 0.05
- nose morphology measurement · score 0.05
- neoplasm · score 0.03
- glioblastoma multiforme · score 0.02
- ovarian carcinoma · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9HAZ1-F1 | alphafold | PREDICTED | 79.08 | — |
Amino-acid sequence (481 residues)
MRHSKRTHCP DWDSRESWGH ESYRGSHKRK RRSHSSTQEN RHCKPHHQFK ESDCHYLEAR SLNERDYRDR RYVDEYRNDY CEGYVPRHYH RDIESGYRIH CSKSSVRSRR SSPKRKRNRH CSSHQSRSKS HRRKRSRSIE DDEEGHLICQ SGDVLRARYE IVDTLGEGAF GKVVECIDHG MDGMHVAVKI VKNVGRYREA ARSEIQVLEH LNSTDPNSVF RCVQMLEWFD HHGHVCIVFE LLGLSTYDFI KENSFLPFQI DHIRQMAYQI CQSINFLHHN KLTHTDLKPE NILFVKSDYV VKYNSKMKRD ERTLKNTDIK VVDFGSATYD DEHHSTLVST RHYRAPEVIL ALGWSQPCDV WSIGCILIEY YLGFTVFQTH DSKEHLAMME RILGPIPQHM IQKTRKRKYF HHNQLDWDEH SSAGRYVRRR CKPLKEFMLC HDEEHEKLFD LVRRMLEYDP TQRITLDEAL QHPFFDLLKK K
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