Very long chain fatty acid elongase 3 (ELOVL3)

About Very long chain fatty acid elongase 3

Very long chain fatty acid elongase 3 (ELOVL3) is a protein from Homo sapiens identified by UniProt accession Q9HB03, 270 residues long. MolForge cross-references it against 0 known binders and 140 disease associations.

Target properties

Protein name	Very long chain fatty acid elongase 3
UniProt accession	Q9HB03
Gene	ELOVL3
Organism	Homo sapiens
Length	270 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (140)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.24
smoking status measurement · score 0.19
alkaline phosphatase measurement · score 0.13
sex hormone-binding globulin measurement · score 0.13
breast adenocarcinoma · score 0.11
Griscelli syndrome type 3 · score 0.06
hypotrichosis simplex · score 0.06
Olmsted syndrome 1 · score 0.06
Clouston syndrome · score 0.05
Griscelli disease · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9HB03-F1	alphafold	PREDICTED	90.58	—

Amino-acid sequence (270 residues)

MVTAMNVSHE VNQLFQPYNF ELSKDMRPFF EEYWATSFPI ALIYLVLIAV GQNYMKERKG FNLQGPLILW SFCLAIFSIL GAVRMWGIMG TVLLTGGLKQ TVCFINFIDN STVKFWSWVF LLSKVIELGD TAFIILRKRP LIFIHWYHHS TVLVYTSFGY KNKVPAGGWF VTMNFGVHAI MYTYYTLKAA NVKPPKMLPM LITSLQILQM FVGAIVSILT YIWRQDQGCH TTMEHLFWSF ILYMTYFILF AHFFCQTYIR PKVKAKTKSQ

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards