About Bcl-2-like protein 12
Bcl-2-like protein 12 (BCL2L12) is a protein
from Homo sapiens identified by UniProt accession
Q9HB09, 250 residues long.
MolForge cross-references it against 0 known binders and
207 disease associations.
Target properties
| Protein name | Bcl-2-like protein 12 |
|---|
| UniProt accession | Q9HB09 |
|---|
| Gene | BCL2L12 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 250 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (207)
Diseases linked to this target (Open Targets).
- skin squamous cell carcinoma · score 0.30
- cutaneous melanoma · score 0.30
- melanoma · score 0.21
- acute myeloid leukemia · score 0.19
- hepatocellular carcinoma · score 0.19
- colorectal adenocarcinoma · score 0.19
- gastric adenocarcinoma · score 0.19
- urinary bladder carcinoma · score 0.19
- colon adenocarcinoma · score 0.19
- prostate adenocarcinoma · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9HB09-F1 | alphafold | PREDICTED | 66.73 | — |
Amino-acid sequence (250 residues)
MAGSEELGLR EDTLRVLAAF LRRGEAAGSP VPTPPRSPAQ EEPTDFLSRL RRCLPCSLGR GAAPSESPRP CSLPIRPCYG LEPGPATPDF YALVAQRLEQ LVQEQLKSPP SPELQGPPST EKEAILRRLV ALLEEEAEVI NQKLASDPAL RSKLVRLSSD SFARLVELFC SRDDSSRPSR ACPGPPPPSP EPLARLALAM ELSRRVAGLG GTLAGLSVEH VHSFTPWIQA HGGWEGILAV SPVDLNLPLD
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