About Potassium channel subfamily K member 13
Potassium channel subfamily K member 13 (KCNK13) is a protein
from Homo sapiens identified by UniProt accession
Q9HB14, 408 residues long.
MolForge cross-references it against 0 known binders and
86 disease associations.
Target properties
| Protein name | Potassium channel subfamily K member 13 |
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| UniProt accession | Q9HB14 |
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| Gene | KCNK13 |
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| Organism | Homo sapiens |
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| Length | 408 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (86)
Diseases linked to this target (Open Targets).
- lung adenocarcinoma · score 0.23
- breast adenocarcinoma · score 0.22
- cutaneous melanoma · score 0.16
- glioblastoma multiforme · score 0.09
- Blackfan-Diamond anemia · score 0.08
- alpha thalassemia-intellectual disability syndrome type 1 · score 0.06
- Alpha-thalassemia - intellectual disability syndrome linked to chromosome 16 · score 0.06
- neutropenia-monocytopenia-deafness syndrome · score 0.05
- Constitutional sideroblastic anemia · score 0.05
- X-linked severe congenital neutropenia · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9HB14-F1 | alphafold | PREDICTED | 74.06 | — |
Amino-acid sequence (408 residues)
MAGRGFSWGP GHLNEDNARF LLLAALIVLY LLGGAAVFSA LELAHERQAK QRWEERLANF SRGHNLSRDE LRGFLRHYEE ATRAGIRVDN VRPRWDFTGA FYFVGTVVST IGFGMTTPAT VGGKIFLIFY GLVGCSSTIL FFNLFLERLI TIIAYIMKSC HQRQLRRRGA LPQESLKDAG QCEVDSLAGW KPSVYYVMLI LCTASILISC CASAMYTPIE GWSYFDSLYF CFVAFSTIGF GDLVSSQNAH YESQGLYRFA NFVFILMGVC CIYSLFNVIS ILIKQSLNWI LRKMDSGCCP QCQRGLLRSR RNVVMPGSVR NRCNISIETD GVAESDTDGR RLSGEMISMK DLLAANKASL AILQKQLSEM ANGCPHQTST LARDNEFSGG VGAFAIMNNR LAETSGDR
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