Potassium channel subfamily K member 12 (KCNK12)

About Potassium channel subfamily K member 12

Potassium channel subfamily K member 12 (KCNK12) is a protein from Homo sapiens identified by UniProt accession Q9HB15, 430 residues long. MolForge cross-references it against 0 known binders and 30 disease associations.

Target properties

Protein name	Potassium channel subfamily K member 12
UniProt accession	Q9HB15
Gene	KCNK12
Organism	Homo sapiens
Length	430 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (30)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.33
gut microbiome measurement · score 0.13
hereditary neoplastic syndrome · score 0.12
Inherited cancer-predisposing syndrome · score 0.12
Lynch syndrome · score 0.12
neurofibrillary tangles measurement · score 0.07
glioblastoma multiforme · score 0.03
ependymoma · score 0.03
atypical teratoid rhabdoid tumor · score 0.02
non-small cell lung carcinoma · score 0.02

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9HB15-F1	alphafold	PREDICTED	73.07	—

Amino-acid sequence (430 residues)

MSSRSPRPPP RRSRRRLPRP SCCCCCCRRS HLNEDTGRFV LLAALIGLYL VAGATVFSAL ESPGEAEARA RWGATLRNFS AAHGVAEPEL RAFLRHYEAA LAAGVRADAL RPRWDFPGAF YFVGTVVSTI GFGMTTPATV GGKAFLIAYG LFGCAGTILF FNLFLERIIS LLAFIMRACR ERQLRRSGLL PATFRRGSAL SEADSLAGWK PSVYHVLLIL GLFAVLLSCC ASAMYTSVEG WDYVDSLYFC FVTFSTIGFG DLVSSQHAAY RNQGLYRLGN FLFILLGVCC IYSLFNVISI LIKQVLNWML RKLSCRCCAR CCPAPGAPLA RRNAITPGSR LRRRLAALGA DPAARDSDAE GRRLSGELIS MRDLTASNKV SLALLQKQLS ETANGYPRSV CVNTRQNGFS GGVGALGIMN NRLAETSASR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards