Pleckstrin homology domain-containing family A member 3 (PLEKHA3)

About Pleckstrin homology domain-containing family A member 3

Pleckstrin homology domain-containing family A member 3 (PLEKHA3) is a protein from Homo sapiens identified by UniProt accession Q9HB20, 300 residues long. MolForge cross-references it against 0 known binders and 35 disease associations.

Target properties

Protein name	Pleckstrin homology domain-containing family A member 3
UniProt accession	Q9HB20
Gene	PLEKHA3
Organism	Homo sapiens
Length	300 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (35)

Diseases linked to this target (Open Targets).

serum alanine aminotransferase measurement · score 0.29
dilated cardiomyopathy 1G · score 0.27
breast adenocarcinoma · score 0.25
aspartate aminotransferase measurement · score 0.24
head and neck squamous cell carcinoma · score 0.19
blood protein measurement · score 0.18
body height · score 0.17
atrial flutter · score 0.14
atrial fibrillation · score 0.14
electrocardiography · score 0.11

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9HB20-F1	alphafold	PREDICTED	71.47	—

Amino-acid sequence (300 residues)

MEGVLYKWTN YLTGWQPRWF VLDNGILSYY DSQDDVCKGS KGSIKMAVCE IKVHSADNTR MELIIPGEQH FYMKAVNAAE RQRWLVALGS SKACLTDTRT KKEKEISETS ESLKTKMSEL RLYCDLLMQQ VHTIQEFVHH DENHSSPSAE NMNEASSLLS ATCNTFITTL EECVKIANAK FKPEMFQLHH PDPLVSPVSP SPVQMMKRSV SHPGSCSSER SSHSIKEPVS TLHRLSQRRR RTYSDTDSCS DIPLEDPDRP VHCSKNTLNG DLASATIPEE SRLMAKKQSE SEDTLPSFSS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards