About Pleckstrin homology domain-containing family A member 1
Pleckstrin homology domain-containing family A member 1 (PLEKHA1) is a protein
from Homo sapiens identified by UniProt accession
Q9HB21, 404 residues long.
MolForge cross-references it against 0 known binders and
206 disease associations.
Target properties
| Protein name | Pleckstrin homology domain-containing family A member 1 |
|---|
| UniProt accession | Q9HB21 |
|---|
| Gene | PLEKHA1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 404 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (206)
Diseases linked to this target (Open Targets).
- type 2 diabetes mellitus · score 0.47
- birth weight · score 0.42
- body height · score 0.41
- lean body mass · score 0.38
- body weight · score 0.37
- fat body mass · score 0.35
- appendicular lean mass · score 0.34
- parental genotype effect measurement · score 0.34
- Thyroid preparation use measurement · score 0.33
- hypothyroidism · score 0.33
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9HB21-F1 | alphafold | PREDICTED | 70.41 | — |
Amino-acid sequence (404 residues)
MPYVDRQNRI CGFLDIEENE NSGKFLRRYF ILDTREDSFV WYMDNPQNLP SGSSRVGAIK LTYISKVSDA TKLRPKAEFC FVMNAGMRKY FLQANDQQDL VEWVNVLNKA IKITVPKQSD SQPNSDNLSR HGECGKKQVS YRTDIVGGVP IITPTQKEEV NECGESIDRN NLKRSQSHLP YFTPKPPQDS AVIKAGYCVK QGAVMKNWKR RYFQLDENTI GYFKSELEKE PLRVIPLKEV HKVQECKQSD IMMRDNLFEI VTTSRTFYVQ ADSPEEMHSW IKAVSGAIVA QRGPGRSASS EHPPGPSESK HAFRPTNAAT ATSHSTASRS NSLVSTFTME KRGFYESLAK VKPGNFKVQT VSPREPASKV TEQALLRPQS KNGPQEKDCD LVDLDDASLP VSDV
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