About Interleukin-1 receptor-like 2
Interleukin-1 receptor-like 2 (IL1RL2) is a protein
from Homo sapiens identified by UniProt accession
Q9HB29, 575 residues long.
MolForge cross-references it against 0 known binders and
225 disease associations.
Target properties
| Protein name | Interleukin-1 receptor-like 2 |
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| UniProt accession | Q9HB29 |
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| Gene | IL1RL2 |
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| Organism | Homo sapiens |
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| Length | 575 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (225)
Diseases linked to this target (Open Targets).
- interleukin 1 receptor-like 2 measurement · score 0.44
- Ascending aortic dissection · score 0.42
- psoriasis · score 0.41
- psoriasis 14, pustular · score 0.38
- immune system disease · score 0.37
- blood protein measurement · score 0.37
- eosinophil count · score 0.36
- interleukin 18 receptor 1 measurement · score 0.26
- acute myeloid leukemia · score 0.24
- childhood onset asthma · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9HB29-F1 | alphafold | PREDICTED | 77.22 | — |
Amino-acid sequence (575 residues)
MWSLLLCGLS IALPLSVTAD GCKDIFMKNE ILSASQPFAF NCTFPPITSG EVSVTWYKNS SKIPVSKIIQ SRIHQDETWI LFLPMEWGDS GVYQCVIKGR DSCHRIHVNL TVFEKHWCDT SIGGLPNLSD EYKQILHLGK DDSLTCHLHF PKSCVLGPIK WYKDCNEIKG ERFTVLETRL LVSNVSAEDR GNYACQAILT HSGKQYEVLN GITVSITERA GYGGSVPKII YPKNHSIEVQ LGTTLIVDCN VTDTKDNTNL RCWRVNNTLV DDYYDESKRI REGVETHVSF REHNLYTVNI TFLEVKMEDY GLPFMCHAGV STAYIILQLP APDFRAYLIG GLIALVAVAV SVVYIYNIFK IDIVLWYRSA FHSTETIVDG KLYDAYVLYP KPHKESQRHA VDALVLNILP EVLERQCGYK LFIFGRDEFP GQAVANVIDE NVKLCRRLIV IVVPESLGFG LLKNLSEEQI AVYSALIQDG MKVILIELEK IEDYTVMPES IQYIKQKHGA IRWHGDFTEQ SQCMKTKFWK TVRYHMPPRR CRPFPPVQLL QHTPCYRTAG PELGSRRKKC TLTTG
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