Cytochrome P450 3A43 (CYP3A43)

About Cytochrome P450 3A43

Cytochrome P450 3A43 (CYP3A43) is a protein from Homo sapiens identified by UniProt accession Q9HB55, 503 residues long. MolForge cross-references it against 0 known binders and 128 disease associations.

Target properties

Protein name	Cytochrome P450 3A43
UniProt accession	Q9HB55
Gene	CYP3A43
Organism	Homo sapiens
Length	503 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (128)

Diseases linked to this target (Open Targets).

HIV infection · score 0.61
HIV-1 infection · score 0.60
COVID-19 · score 0.58
AIDS · score 0.58
chronic hepatitis C virus infection · score 0.57
infection · score 0.55
hepatitis C virus infection · score 0.55
HIV-Associated Lipodystrophy Syndrome · score 0.46
coronavirus infectious disease · score 0.43
cancer · score 0.40

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9HB55-F1	alphafold	PREDICTED	91.78	—

Amino-acid sequence (503 residues)

MDLIPNFAME TWVLVATSLV LLYIYGTHSH KLFKKLGIPG PTPLPFLGTI LFYLRGLWNF DRECNEKYGE MWGLYEGQQP MLVIMDPDMI KTVLVKECYS VFTNQMPLGP MGFLKSALSF AEDEEWKRIR TLLSPAFTSV KFKEMVPIIS QCGDMLVRSL RQEAENSKSI NLKDFFGAYT MDVITGTLFG VNLDSLNNPQ DPFLKNMKKL LKLDFLDPFL LLISLFPFLT PVFEALNIGL FPKDVTHFLK NSIERMKESR LKDKQKHRVD FFQQMIDSQN SKETKSHKAL SDLELVAQSI IIIFAAYDTT STTLPFIMYE LATHPDVQQK LQEEIDAVLP NKAPVTYDAL VQMEYLDMVV NETLRLFPVV SRVTRVCKKD IEINGVFIPK GLAVMVPIYA LHHDPKYWTE PEKFCPERFS KKNKDSIDLY RYIPFGAGPR NCIGMRFALT NIKLAVIRAL QNFSFKPCKE TQIPLKLDNL PILQPEKPIV LKVHLRDGIT SGP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards