About Sp110 nuclear body protein
Sp110 nuclear body protein (SP110) is a protein
from Homo sapiens identified by UniProt accession
Q9HB58, 689 residues long.
MolForge cross-references it against 0 known binders and
48 disease associations.
Target properties
| Protein name | Sp110 nuclear body protein |
|---|
| UniProt accession | Q9HB58 |
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| Gene | SP110 |
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| Organism | Homo sapiens |
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| Length | 689 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (48)
Diseases linked to this target (Open Targets).
- Hepatic veno-occlusive disease - immunodeficiency · score 0.73
- hepatic veno-occlusive disease-immunodeficiency syndrome · score 0.72
- insulin like growth factor measurement · score 0.27
- IGF-1 measurement · score 0.26
- chronic lymphocytic leukemia · score 0.25
- Crohn's disease · score 0.24
- eosinophil count · score 0.23
- genetic disorder · score 0.19
- tuberculosis · score 0.18
- multiple sclerosis · score 0.15
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9HB58-F1 | alphafold | PREDICTED | 57.99 | — |
Amino-acid sequence (689 residues)
MFTMTRAMEE ALFQHFMHQK LGIAYAIHKP FPFFEGLLDN SIITKRMYME SLEACRNLIP VSRVVHNILT QLERTFNLSL LVTLFSQINL REYPNLVTIY RSFKRVGASY EWQSRDTPIL LEAPTGLAEG SSLHTPLALP PPQPPQPSCS PCAPRVSEPG TSSQQSDEIL SESPSPSDPV LPLPALIQEG RSTSVTNDKL TSKMNAEEDS EEMPSLLTST VQVASDNLIP QIRDKEDPQE MPHSPLGSMP EIRDNSPEPN DPEEPQEVSS TPSDKKGKKR KRCIWSTPKR RHKKKSLPGG TASSRHGIQK KLKRVDQVPQ KKDDSTCNST VETRAQKART ECARKSRSEE IIDGTSEMNE GKRSQKTPST PRRVTQGAAS PGHGIQEKLQ VVDKVTQRKD DSTWNSEVMM RVQKARTKCA RKSRLKEKKK EKDICSSSKR RFQKNIHRRG KPKSDTVDFH CSKLPVTCGE AKGILYKKKM KHGSSVKCIR NEDGTWLTPN EFEVEGKGRN AKNWKRNIRC EGMTLGELLK RKNSDECEVC CQGGQLLCCG TCPRVFHEDC HIPPVEAKRM LWSCTFCRMK RSSGSQQCHH VSKTLERQMQ PQDQLIRDYG EPFQEAMWLD LVKERLITEM YTVAWFVRDM RLMFRNHKTF YKASDFGQVG LDLEAEFEKD LKDVLGFHEA NDGGFWTLP
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