About Netrin-4
Netrin-4 (NTN4) is a protein
from Homo sapiens identified by UniProt accession
Q9HB63, 628 residues long.
MolForge cross-references it against 0 known binders and
186 disease associations.
Target properties
| Protein name | Netrin-4 |
|---|
| UniProt accession | Q9HB63 |
|---|
| Gene | NTN4 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 628 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (186)
Diseases linked to this target (Open Targets).
- urate measurement · score 0.45
- cortical surface area measurement · score 0.39
- blood protein measurement · score 0.37
- colorectal cancer · score 0.36
- FEV/FVC ratio · score 0.31
- diastolic blood pressure · score 0.31
- brain measurement · score 0.31
- polyp of colon · score 0.30
- osteoarthritis · score 0.29
- arterial stiffness measurement · score 0.24
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9HB63-F1 | alphafold | PREDICTED | 83.81 | — |
Amino-acid sequence (628 residues)
MGSCARLLLL WGCTVVAAGL SGVAGVSSRC EKACNPRMGN LALGRKLWAD TTCGQNATEL YCFYSENTDL TCRQPKCDKC NAAYPHLAHL PSAMADSSFR FPRTWWQSAE DVHREKIQLD LEAEFYFTHL IVMFKSPRPA AMVLDRSQDF GKTWKPYKYF ATNCSATFGL EDDVVKKGAI CTSKYSSPFP CTGGEVIFKA LSPPYDTENP YSAKVQEQLK ITNLRVQLLK RQSCPCQRND LNEEPQHFTH YAIYDFIVKG SCFCNGHADQ CIPVHGFRPV KAPGTFHMVH GKCMCKHNTA GSHCQHCAPL YNDRPWEAAD GKTGAPNECR TCKCNGHADT CHFDVNVWEA SGNRSGGVCD DCQHNTEGQY CQRCKPGFYR DLRRPFSAPD ACKPCSCHPV GSAVLPANSV TFCDPSNGDC PCKPGVAGRR CDRCMVGYWG FGDYGCRPCD CAGSCDPITG DCISSHTDID WYHEVPDFRP VHNKSEPAWE WEDAQGFSAL LHSGKCECKE QTLGNAKAFC GMKYSYVLKI KILSAHDKGT HVEVNVKIKK VLKSTKLKIF RGKRTLYPES WTDRGCTCPI LNPGLEYLVA GHEDIRTGKL IVNMKSFVQH WKPSLGRKVM DILKRECK
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